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T. muris is a useful model organism for studying host parasite relationships and associated immune responses as it is closely related to the human parasite T. trichuria, known as the human whipworm, which is thought to infect a quarter of the World's population. Infection is usually asymptomatic, but can cause vitamin A deficiency in children, resulting in stunted growth and developmental delay in children.


Adult worms are approximately 1 centimeter long

Trichuris muris is a parasitic nematode affecting mice. Following ingestion, T. muris eggs hatch in the large intestine where they develop into adults. The anterior end of the worm burrows into the lining of the gut, leaving the posterior end protruding into the lumen of the gut. The worms mate in this orientation, and the resulting eggs are released in to the gut lumen and shed faecally. 

Confocal micrograph of part of a mouse kidney. Optical slices were taken at various depths through a fluorescently stained piece of kidney tissue (total depth 12 micrometres). A 3D image was reconstructed from these images and the colours adjusted to display a rainbow colour depth map. Different depths in the sample are visualised with different colours (red, orange, yellow, green, blue from top to bottom). Kidneys are vital organs which filter the blood and make urine. The glomerulus (larger structure; middle left) and tubules are visible. The glomerulus is a cluster of capillaries through which blood is filtered. It sits in the Bowman's capsule at one end of the nephron. Horizontal width of image is 200 micrometres.

Mouse kidney

Fluorescence micrograph of the head of a mouse embryo viewed from the front. Parts of the brain have been stably labelled with a fluorescent protein (green; EYFP) in order to visualise them as the mouse develops. At this stage of development (embryonic day 13.5) the forebrain and the eyes are visible. In this image the dark pigmentation of the eyes are partially covering the fluorescence signal. Width of image is approximately 5 mm.

Mouse embryo head viewed from the front

False-coloured transmission electron micrograph of tissue from the medial prefrontal cortex in a mouse brain. This region of the brain is important for social behaviour, emotions and psychiatric disorders such as depression. In the centre of the image are two nerve fibres (axons; coloured green and purple) each surrounded by myelin (thick black line). Axons are long projections which extend out from nerve cells (neurones) and carry electrical impulses or signals to other cells. Myelin forms a protective sheath or insulating layer around some nerve fibres. It allows electrical impulses to travel quickly along the nerve cells. If it is damaged these impulses slow down and can cause diseases such as multiple sclerosis. Width of image is approximately 4 micrometres.

Myelinated nerves in a mouse brain, TEM

A colony of undifferentiated mouse embryonic stem cells growing in culture in serum-free conditions without feeder cells.

Mouse embryonic stem cells

A colony of undifferentiated mouse embryonic stem cells growing in culture in serum-free conditions without feeder cells. The cells have very prominent nucleoli.

Polarised light micrograph of a transverse section through a mouse head across the nasal region. This slide mount was made by Thomas Russell between 1868 and 1901. Blood vessels were injected with dye before fixing and sectioning the tissue in order to visualise the capillary bed. Polarised light microscopy was used together with dark ground illumination to capture this image. Composite of 18 individual images stitched together. Horizontal width of image is 5 mm.

Mouse nose, transverse section

Freeze-fracture scanning electron micrograph of a blood vessel that has grown into a melanoma and is providing nourishment to it. Numerous blood cells can be seen within the blood vessel. This is surrounded by the melanoma which is from mouse skin. Horizontal width of image is approximately 230 micrometres.

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Mouse embryo head viewed from the front

Myelinated nerves in a mouse brain, TEM

Mouse embryonic stem cells

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Mouse nose, transverse section

Blood vessel in a melanoma, SEM

Mouse embryonic stem cells

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Mouse kidney

Mouse embryo head viewed from the front

Myelinated nerves in a mouse brain, TEM

Mouse embryonic stem cells

Mouse embryonic stem cells

Mouse embryonic stem cells

Mouse nose, transverse section

Blood vessel in a melanoma, SEM

Mouse embryonic stem cells

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