Brown Adipose tissue, murine, THG

  • Daniela Malide, NIH, Bethesda, USA
  • Digital Images
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Brown Adipose tissue, murine, THG. Daniela Malide, NIH, Bethesda, USA. Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). Source: Wellcome Collection.

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3D reconstruction of brown adipose tissue from a mouse. Brown adipose cells each with multiple round, grape-like, lipid droplets (coloured red) are visible. Blood vessels (not visible here) will lie in the spaces separating the cells. In the mouse, brown adipose tissue is primarily found between the shoulder blades (scapulae) and plays a key role in helping to maintain core body temperature. This image was acquired by label-free third harmonic generation microscopy (THG) which is a type of two-photon microscopy used to visualise naturally occurring non-fluorescent signals from biological samples. Width of image is 250 micrometres with the diameter of each cell approximately 30 micrometres.

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