'A Plan for Evaluating Potential Drugs'

File consists of final versions of a chapter, draft chapters and correspondence related to the book chapter by J.R. Vane, "A Plan for Evaluating Potential Drugs", in the book by Laurence and Bacharach (editors), Evaluation of Drug Activities: Pharmacometrics, (London: Academic Press, 1964). Vane's chapter was initially called , "A General Plan for Screening Tests", and most of the drafts are under this title rather than the final title as published. Details include:

Letter from Vane to Academic Press regarding royalties, dated 2 April 1965.

Letter from Academic Press to Vane referring to enclosure of a copy of the published book, dated 16 December 1964.

Letter from Glaxo Laboratories to Vane regarding the use of a diagram that was going to appear in the book chapter for another book called The Glaxo Volume.

Letter dated 12 April 1964 from A.L. Bacharach to Vane discussing final amendments to the chapter and accreditations.

Letters from Mary Waldron to Vane and also Vane to Mary Waldron, dated 21 and 25 November 1963 respectively, regarding amendments to one of the diagrams to be used in the chapter.

Letter to Dr Bacharach dated 7 November 1963 with detailed comments on the printer's typeset proofs of the chapter. The amended proofs accompany the letter.

Typed sheet of comments on the Appendix dated 25 July 1963.

Letter dated 10 July 1963 from A.L. Bacharach with redraft suggestions for Vane's chapter, particularly with regard to the tables and appendix.

Letter dated 5 July 1963 from Vane to Desmond Laurence at University College Hospital Medical School. The letter refers to adding an appendix and changing the tables.

Proposed appendix for the chapter (2 versions).

Photographs of the figures to be used in the chapter (labelled 13/37A and 13/37/B).

Letters to Dr Bacharach from Vane, with amendments to the chapter and responding to questions, dated 27 May 1963 and 24 June 1963.

Letter from Samuel Irwin, Head of Neuropharmacology Research at Schering Corporation of New Jersey, USA, dated 20 May 1963. The letter refers to the publication date of certain papers.

Letters to Vane from Laurence and Bacharach acknowledging receipt of his draft (13 May 1963) and setting out an extensive list of comments (18 May 1963).

Letter from Vane to Dr Laurence referring to the enclosure of the first draft of the chapter.

Letters to Vane from Academic Press, chasing Vane for a draft of his chapter, and providing a revised scope, dated 26 December 1962 and 28 February 1963.

Detailed scope for the whole book which was originally called, "Screeing for Drug Action".

Initial letter to Vane from Academic Press, discussing the intention to publish the book, dated 8 May 1961.

4 different drafts of the chapter, some with amendments, and one includes the comments of H.O.J. Collier. There is also a handwritten and coloured diagram for inclusion as one of the figures in the chapter.

Copy of the reference list for the chapter.

Copy of the wording to accompany the figures used in the chapter.

Papers of Sam Irwin at Schering Corporation who assisted with the provision of some information that Vane was to use as a basis for the chapter. The papers include Schering Corporations's Behvioural Evaluation Record Sheet, a paper on the "Behavioural Evaluation of Cat and Dog", typed papers on "Effects of Chronic Methamphetamine Administration in the Cat" and "Correlation Between Locomotor Stimulant and Brain Monoamineoxidase-inhibitory Activity of Iproniazid, Nialamide and Pheniprazine in the Rat", and various handwritten notes and cards.

Drug test sheet results from companies that agreed to take part in the research on which Vane's chapter was based.

Correspondence with drug companies which both agreed and refused to participate in the research for the chapter.

1961-1964

2 files

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