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Sympamines and Tryptamines

  • Vane, Sir John, FRS (1927-2004), Pharmacologist
Date
1957-1960
Reference
PP/JRV/B/3/7
Part of
Vane, Sir John Robert (1927-2004)
  • Archives and manuscripts

About this work

Description

File contains a notebook with the title on the spine, "Sympamines and Tyrptamines, 57-59". The notebook contains details of experiment methodology, handwritten results, tables and graphs regarding sympamines and tryptamines experiments. Details in the notebook include:

An index to the sympamines and tryptamines experiments cross-referencing each substance (alphabetically) with its related experiments and the organs used to their related experiments.

Under the title, "Sympathomimetic Amines" there is a summary of the experiments in Stomach Book 2.

The first experiment begins on 21 March 1957 (experiment SA4) and the first set of experiments last until 25 September 1957 (experiments SA36a&b).

A series of notes summarising published material on the subject from several books and journals including:

G. Barger & H.H. Dale, "Chemical Structure & Sympathomimetic Action of Amines", Journal of Physiology, vol.41 no.1-2, p19-59, 11 October 1910.

Marsh, Howard & Herring, "The Comparative Pharmacology of the Hydroxy and Methyl Derivatives of 6-Methyl-2-Heptylamine", Journal of Pharmacology and Experimental Therapeutics, vol.103, p178-186 (1951).

K.H. Beyer, "The Relation of Structure to their Action and Inactivation", Physiological Reviews, vol.26 no.2, p169-197, April 1946.

J.H. Gaddum & H. Kwiatkowski, "The Action of Ephedrine", Journal of Physiology, vol.94, p87-100 (1938).

O. Schaumann, "Uber Oxy-Ephedrine", Archives of Experimental Pathology in Pharmakology, vol.160, p127-176 (1931).

F.H. Bumpus & I.H. Page, "Serotonin and its Methylated Derivatives in Human Urine", Journal of Biological Chemistry, vol.212, p111-116 (1955).

V. Erspamer, "Biological Activity of Some Enteramine-related Substances", Nature, vol.170, p281-282 (1952).

G. Reid & M. Rand, "Pharmacological Actions of Synthetic 5-Hydroxytryptamine (Serotonin, Thrombocytin)", Nature, vol.169, p801-802, 10 May 1952.

K.K. Chen & A.L. Chen, "The Pharmacological Action of Ten Amines Related to Ephedrine and Tryptamine", Journal of the American Phaceutical Association, vol.xxii, p813, (1933).

The second series of experiments begin with SA38-40 (undated), then SA41b (25 October 1957) and run until 15 March 1958 (experiment SA65(3)).

A new set of experiments start with AO1 (17 March 1958) and end with AO14 (6 May 1958).

The SA experiments begin again with SA66 (2 April 1958) and run to SA181 (18 December 1960). This write up of this series of experiments includes a summary of blood bathed stomach strip experiments, a summary of blood bathed organ experiments (SA71-146), a list of possible illustrations, a list of experiments required to complete the "paper", a list of reasons for tone change, and a reappraisal of whole animal experiments (dated 15 June 1959).

Publication/Creation

1957-1960

Physical description

1 file

Acquisition note

219

Finding aids

Wellcome Library online catalogue

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