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Stories

  • Article

London, city of lost hospitals

Come on the trail of hundreds of ghost hospitals, whose remnants hold clues to medical treatments of the past.

  • Article

A brief history of ventilation

As ventilators continue to play an important part in helping very ill coronavirus patients, medical historian Dr Lindsey Fitzharris traces their development from the first attempts at mouth-to-mouth resuscitation through centuries of medical crises.

  • Article

Inhaling happiness and gasping for a high

The rapid, short-lived high we get from whippets, reefers and vapes can be accompanied by long-term health consequences. The search is on for safer ways to get stoned.

  • Article

Deadly doses and the hardest of hard drugs

The invention of the modern hypodermic syringe meant we could get high – or accidentally die – faster than before. Find out how this medical breakthrough was adapted for deadly uses.

All stories (48)

Images

  • Veratrum nigrum L. Melanthiaceae Distribution: Europe. Cows do not eat Veratrum species in the meadows, and human poisoning with it caused vomiting and fainting. In the 1850s it was found to reduce the heart's action and slow the pulse (Bentley, 1861, called it an 'arterial sedative'), and in 1859 it was used orally in a woman who was having convulsions due to eclampsia. Dr Paul DeLacy Baker in Alabama treated her with drops of a tincture of V. viride. She recovered. It was used thereafter, as the first choice of treatment, and, when blood pressure monitoring became possible, it was discovered that it worked by reducing the high blood pressure that occurs in eclampsia. By 1947 death rates were reduced from 30% to 5% by its use at the Boston Lying-in Hospital. It works by dilating the arteries in muscles and in the gastrointestinal circulation. A further use of Veratrum species came to light when it was noted that V. californicum - and other species - if eaten by sheep resulted in foetal malformations, in particular only having one eye. The chemical in the plant that was responsible, cyclopamine, was found to act on certain genetic pathways responsible for stem cell division in the regulation of the development of bilateral symmetry in the embryo/foetus. Synthetic analogues have been developed which act on what have come to be called the 'hedgehog signalling pathways' in stem cell division, and these 'Hedgehog inhibitors' are being introduced into medicine for the treatment of various cancers like chondrosarcoma, myelofibrosis, and advanced basal cell carcinoma. The drugs are saridegib, erismodegib and vismodegib. All the early herbals report on its ability to cause vomiting. As a herbal medicine it is Prescription Only, via a registered dentist or physician (UK Medicines and Healthcare Products Regulatory Agency (MHRA)). Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • Veratrum album L. Melanthiaceae Distribution: Europe. Cows do not eat Veratrum species in the meadows, and human poisoning with it caused vomiting and fainting. In the 1850s it was found to reduce the heart's action and slow the pulse (Bentley, 1861, called it an 'arterial sedative'), and in 1859 it was used orally in a woman who was having convulsions due to eclampsia. Dr Paul DeLacy Baker in Alabama treated her with drops of a tincture of V. viride. She recovered. It was used thereafter, as the first choice of treatment, and when blood pressure monitoring became possible, it was discovered that it worked by reducing the high blood pressure that occurs in eclampsia. By 1947 death rates were reduced from 30% to 5% by its use at the Boston Lying in Hospital. It works by dilating the arteries in muscles and in the gastrointestinal circulation. A further use of Veratrum species came to light when it was noted that V. californicum -and other species - if eaten by sheep resulted in foetal malformations, in particular only having one eye. The chemical in the plant that was responsible, cyclopamine, was found to act on certain genetic pathways responsible for stem cell division in the regulation of the development of bilateral symmetry in the embryo/foetus. Synthetic analogues have been developed which act on what have come to be called the 'hedgehog signalling pathways' in stem cell division, and these 'Hedgehog inhibitors' are being introduced into medicine for the treatment of various cancers like chondrosarcoma, myelofibrosis, and advanced basal cell carcinoma. The drugs are saridegib, erismodegib and vismodegib. All the early herbals report on its ability to cause vomiting. As a herbal medicine it is Prescription Only, via a registered dentist or physician (UK Medicines and Healthcare Products Regulatory Agency (MHRA)). Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • Wellcome Historical Medical Museum, Wigmore Street, London: the galleried Hall of Statuary. Photograph.
  • Wellcome Historical Medical Museum, Wigmore Street, London: the galleried Hall of Statuary. Photograph.
  • Wellcome Historical Medical Museum, Wigmore Street, London: a head-hunter's hut, south east New Guinea, in the Hall of Primitive Medicine. Photograph.
  • Wellcome Historical Medical Museum, Wigmore Street, London: a head-hunter's hut, south east New Guinea, in the Hall of Primitive Medicine. Photograph.
  • Wellcome Historical Medical Museum, Wigmore Street, London: west wall of the Gallery of Pictures. Photograph.
  • A map of Paraguay and surrounding area, illustrating where cinchona (quinine) was allegedly first discovered in 1626(?). Etching by D.V. Rossi.
  • A map of the area of Villcabamba, Ecuador, illustrated with buildings, rivers, people, animals and flowering plants and trees. Watercolour.
  • An obese midwife on her way to a labour in the early hours of the morning. Coloured etching by T. Rowlandson, 1811.
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