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  • Article

A quick guide to drugs, the brain and brain chemistry

Discover some of the major chemicals that govern activity in our brains, how they work, and why certain drugs have the effects they do.

  • Article

Dating on dopamine

Drug treatment for Parkinson’s can come with an unwanted side serving of compulsive behaviour, as Pete Langman discovered. Read about his dating journey in a dopamine cloud.

  • Article

The solidarity of sickness

Visiting an injured friend in hospital prompts writer Sinéad Gleeson to reflect on the instant rapport forged between compatriots in the kingdom of the sick.

  • Book extract

The history of brainwashing

Is it possible to control what other people think? In this abridged extract from his book ‘Brainwashed’, psychoanalyst and historian Daniel Pick offers us a new history of thought control.

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  • Catharanthus roseus (L.)G.Don Apocynaceae. Madagascar Periwinkle Distribution: Madagascar. It is the source of vincristine and vinblastine, which impair cell multiplication by interfering with microtubule assembly, causing metaphase arrest and are effective medications for leukaemias, lymphomas and some solid tumours. The mortality from childhood leukaemia fell from 100% to 30% once it was introduced - not a drug that could ethically be tested by double-blind trials. These chemicals were initially discovered by investigators in 1958 who were looking for cures for diabetes so tested this plant which was being used in the West Indies to reduce blood sugar levels. There are 70 different alkaloids present in this plant, and some - catharanthine, leurosine sulphate, lochnerine, tetrahydroalstonine, vindoline and vindolinine - lower blood sugar levels. However, the toxicity of this plant is such that this is not a plant to try at home for diabetic management. The vincristine content of the plant is 0.0003%, so two kilograms of leaf are required to produce sufficient vincristine for a single course of treatment for a child (6gm). Fortunately it is a vigorous weed and easy to grow in the tropics. Artificial synthesis has now been achieved. Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • A sunflower, a symbol of bringing life back by giving blood; an AIDS prevention advertisement by the AIIMS Blood Transfusion Service and NGO AIDS Cell, New Delhi. Colour lithograph by N.R. Nanda, ca. January 1994.
  • A sunflower, a symbol of bringing life back by giving blood; an AIDS prevention advertisement by the AIIMS Blood Transfusion Service and NGO AIDS Cell, New Delhi. Colour lithograph by N.R. Nanda, ca. January 1994.
  • Brain Organoid.
  • Charcot Leyden crystals from an endobronchial lesion
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