On some conditions determining variations in the energy of tumor growth / by Leo Loeb.

  • Loeb, Leo, 1869-1959.
Date:
1905
Catalogue details

Licence: In copyright

Credit: On some conditions determining variations in the energy of tumor growth / by Leo Loeb. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

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    ON SOME CONDITIONS DETERMINING VARIATIONS IN THE ENERGY OF TUMOR GROWTH. BY LEO LOEB, M.D., of Philadelphia. (From the Pathologic Laboratory of the University of Pennsylvania.) In the following, I intend to communicate certain of the observations on the energy of tumor growth, and especially on experimentally produced variations, of the rate of growth which were made in the course of four series of consecutive transplantations of tumors, three of which have already been discussed mainly in regard to other problems. The fourth series, a fuller report on which shall be published soon, concerned the transplan- tation of a mixed tumor of the submaxillary gland found in a Japanese (waltzing) mouse. In a provisional way, it may be stated that two vari- able factors determine the rate of tumor growth : 1. Certain conditions present in the organism and probably in part, at least, in the lymph and blood of the animal in which the tumor is growing. 2. The energy of growth of the tumor, either inherent in the tumor cells or modified by certain environmental conditions other than those named under No. 1. These two sets of factors being both variable, only a long series of observations will enable us to analyze the sphere of influence of each of them. At present, the analysis must of necessity be still very incomplete. In legard to the first of these two factors, a number of interesting facts has been established by different investigators. The transplanted tumors will not o-row in animals of different species. The salivary tumor of me .Japanese mouse did not grow in a white mouse. I succeeded, however, in inoculating a sarcoma of a white rat into a hybrid between a white and gray rat. Yensen succeeded in a restricted number of cases in transplanting