Microtome used in the 1850's. It was introduced by C.M. Topping, a famous preparer of microscope slides in the 1840's. It came into general use in the 1850's. The thickness of section was controlled by the micrometer screw.

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Credit: Microtome used in the 1850's. It was introduced by C.M. Topping, a famous preparer of microscope slides in the 1840's. It came into general use in the 1850's. The thickness of section was controlled by the micrometer screw. Wellcome Collection. Source: Wellcome Collection.