Microtome used in the 1850's. It was introduced by C.M. Topping, a famous preparer of microscope slides in the 1840's. It came into general use in the 1850's. The thickness of section was controlled by the micrometer screw.

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Microtome used in the 1850's. It was introduced by C.M. Topping, a famous preparer of microscope slides in the 1840's. It came into general use in the 1850's. The thickness of section was controlled by the micrometer screw. Wellcome Collection. Attribution 4.0 International (CC BY 4.0). Source: Wellcome Collection.