Studies in isoagglutination. II. The occurrence of grouped isoagglutination in the lower animals / by Reuben Ottenberg and S.S. Friedman.

  • Ottenberg, Reuben, 1882-1959.
Date:
1911
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Licence: In copyright

Credit: Studies in isoagglutination. II. The occurrence of grouped isoagglutination in the lower animals / by Reuben Ottenberg and S.S. Friedman. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

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    9 STUDIES IN ISOAGGLUTINATION. II. THE OCCURRENCE OF GROUPED ISOAGGLUTINA- TION IN THE LOWER ANIMALS.* By REUBEN OTTENBERG and S. S. FRIEDMAN. {From the Laboratory of Biological Chemistry of Columbia University, at the College of Physicians and Surgeons, and the Pathological Laboratory of Mount Sinai Hospital, New York.) In the previous paper of this series/ the isoagglutinins which occur in nearly all human bloods, and according to which all human beings can be divided into four sharply separated groups, were dis- cussed. For some time it has seemed to us that a constant and hereditary characteristic like this grouping must have some very fundamental significance, and is not likely to be limited to one spe- cies of animal. Throughout the literature it is stated that normal isoagglutinins occur only in human beings. Von Dungern has recently shown that immune isoagglutinins can be developed in dogs by treating them with each other’s blood, and that two isoagglutinable sub- stances occur in dog bloods. He has also shown, with the method of absorption of agglutinins from animal sera by human red blood cells, that the serum of many animals contains agglutinins which have the same selective activity on human cells as that shown by human isoagglutinins. Likewise he has demonstrated by the ab- sorption method with human sera and the red cells of other animals, that the cells of many other animals contain agglutinable substances * Received for publication, March 17, 1911. This study is one of a projected series on isoagglutination, which in turn constitutes a section of a comprehensive plan of research on the composition of protoplasm, as well as the structural and dynamic relationships of cell constituents and products. These investiga- tions are now in progress in the Laboratory of Biological Chemistry of Columbia University, at the College of Physicians and Surgeons, and under the auspices of the George Crocker Special Research Fund. ' Ottenberg, Jour. Exper. Med., 1911, xiii, 425.