Process for production of readily resorbent medicated soaps or ointments / [Rudolf Reiss].

  • Reiss, Rudolf.
Date:
1904
Catalogue details

Licence: Public Domain Mark

Credit: Process for production of readily resorbent medicated soaps or ointments / [Rudolf Reiss]. Source: Wellcome Collection.

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    N'’ 24,240 A.D. 190a Date of Application, 9th Nov., 1903—Accepted, 7th Jan., 1904 COMPLETE SPEICIFICATION. “ Process for Production of Readily Resorbent Medicated Soaps or Ointments I, Rudolf Reiss, Doctor of Cliemistry of, Charlotteiiburg, EneseLeckstrasse 27, in tke Empire of Germany, do hereby declare the nature of this invention and in what manner the same is to be performed, to be particularly described and :• i;ascertained in and by the following statement: — 5 The subject of tbe present invention deals witli the manufacture of soap in ointment form for medicinal purposes. It is already known that ointment soaps as media of medical agents possess in comparison with ordinary ointments, principally on account of tbeir great capacity of reabsorption, high dermatalogical value. Isuvertbeless, bitberto it ]() bas not proven successful to manufacture ointment soaps witb wbicb tberapeuti- cally valuable medicaments bave been incorporated, as sooner or later sucb soaps decompose, in consequence of wbicb tbe purposed medicainental effect of tbe in¬ corporated substance, or substances, is lost. Eow I bave discovered tbat tbei cause of tbis deconiposition aforesaid is tbe 15 presence of water in tbe soap serving as tbe base. Tbis water causes decom« position of tbe soap base, and also a union of tbe liberated alkali witb tbe added medicameiital substance, witb tbe liberation of fatty acid. Now tberefore -f water be alltogetber excluded in tbe manufacture of medicated ointment soaps it becomes possible, as I bave discovered, to produce sucb a soap wbicb will 20 keep permanently, i.e. will not by deconiposition lose its medicamental pro¬ perties. Sucb a water-freed soap base can be obtained by any known metbod of freeing any prepared alkali soap of water, but it bas been proven to be materially more advantageous to combine tbe formation of tbe soap base and tbe manu¬ facture of tbe medicated soap itself in a single process. It is of course essential 25 therein that the added medicated substance be retained as sucb in tbe ointment soap, i.e. tbat no free alkali whatever be present therein, for substances of tbis nature agglutinated with alkali are not taken up by tbe skin and are tberefore entirely useless for the purposes in question. To obtain increased power of reabsorption of the soap base, and also to get a 30 homogeneous soap mass, tbe fatty acid is retained in excess. As medioamental substances salicylic acid, benzoic acid, cinnamic acid (pbenyl- acrylic acid), kinic acid, and tbeir esters, guiacol-sulpbo acid (di-oxid-benzol- anetbyl-etber-sulpbo acid), carbon-sulpbonic acid (etbyl-sulphonic acid), sub¬ limate or chloride of quicksilver (deuto-cbloride of mercury), halogen, tbeir coni- 3- binations and the like come chiefly into consideration, which wbeii water is ' present produce decomposition in the soap substance. It is serviceable to add to tbis medicated soap paraffine or vaseline preparations of olefiant or unguentous consistency, as used in medicine. The process in general is the following: —The fattv acid to serve as the soap base is melted together with tbe vaseline or 40 paraffine preparation, and is then gradually compounded witb a quantity of a fixed alkali, insufficient for saturation of tbe fatty acid, in watery or any alcoholic solution. When the alkali is completely bound tbe water is completely driven out of tbe soft soap mass so obtained by beating to the requisite tem¬ perature. As is self evident this beating can be done in vacuo in order to be able