A preliminary report on a study of the protective ferments of the blood by the Abderhalden method, after the transplantation of organs / by Charles Goodman, M.D.

  • Goodman, Charles
Date:
[1915?]
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Licence: In copyright

Credit: A preliminary report on a study of the protective ferments of the blood by the Abderhalden method, after the transplantation of organs / by Charles Goodman, M.D. Source: Wellcome Collection.

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    ■/Vith the Authors Compliments REPRINTED FROM ANNALS OR SURGERY 227 South Sixth Street, Philadelphia, Penna. February, 1915. A PRELIMINARY REPORT ON A STUDY OF THE PRO¬ TECTIVE FERMENTS OF THE BLOOD BY THE ABDER- HALDEN METHOD, AFTER THE TRANSPLANTATION OF ORGANS * By Charles Goodman, M.D. of New York At the recent meeting of the International Congress of Surgeons, Carrel reiterated his former statements to the effect that he had met with considerable success in autotransplantation but that homotrans¬ plantation of an organ, such as the kidney, was only temporarily suc¬ cessful, it invariably showing degenerative changes within a few days. Lexer, on the other hand, showed that he had succeeded in overcoming some of the biochemical reactions between his animals by a prolonged preliminary treatment of the host with tissues and blood serum taken from the donor. Blood-vessels transplanted with proper precautions retain their vitality, become an integral part of the system and are believed to re¬ main without extensive tissue metamorphosis. But when parenchymatous organs with a more complicated phy¬ siological function, such as the kidney, the spleen and the thyroid, are transplanted the results as stated are different. They soon undergo autolytic changes and eventually become absorbed. This is known to be caused by biochemical reactions but may be due in part to injury incident to deficient venous drainage, and the technic about to be described is thought to minimize such injuries. For an interval after an organ is transplanted, it remains in a state of vasomotor paralysis, and is apt to become overdistended with blood on account of insufficient venous drainage. Before appreciating the value of and employing end-to-end anastomosis I had found it neces¬ sary to split the kidney capsule in order to prevent parenchymatous destruction by hypertension. In transplanting the kidney of one dog to the neck of another, one may unite the renal artery end to side to the carotid, but the stoma of the renal vein (Figs. 1, 2 and 3) should be placed end-to-end with that of the external jugular. This I consider very important, because it creates immediate venous drainage for the transplant on account of the * From the Laboratory of Experimental Surgery, New York University.