Studies in isoagglutination. I. Transfusion and the question of intravascular agglutination / by Reuben Ottenberg.

  • Ottenberg, Reuben, 1882-1959.
Date:
1911
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Licence: In copyright

Credit: Studies in isoagglutination. I. Transfusion and the question of intravascular agglutination / by Reuben Ottenberg. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

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    /O, STUDIES IN ISOAGGLUTINATION. I. TRANSFUSION AND THE QUESTION OF INTRA- VASCULAR AGGLUTINATION.* By REUBEN OTTENBERG. (From the Pathological Laboratory of Mount Sinai Hospital and the Labora- tory of Biological Chemistry of Columbia University, College of Physicians and Surgeons, New York.) INTRODUCTION. This paper offers a solution of a special problem in isoagglutina- tion; namely, the question whether transfusion is permissible be- tween persons whose sera agglutinate the red blood cells of each other. It also shows why such transfusions are not regularly fol- lowed by serious symptoms. The isoagglutination of human red blood cells was discovered independently by Landsteiner and by Shattock in 1900. Many workers at first regarded the phenomenon as one of pathological significance. Halban, Ascoli, and others, however, showed that isoagglutination occurred with a large proportion of normal bloods, and Landsteiner discovered the remarkable fact that all human bloods can be divided into three sharply defined groups, according to the way in which they interagglutinate. To these groups was subsequently added a fourth, independently discovered by several observers. The groups are as fol- lows (see table 1) : The serum of the first group, designated in this paper as group I, possesses the power of agglutinating the red cells of members of all the other groups, but the red cells of members of group I are not agglutinated by any human serum. This group includes about 50 per cent, of all persons examined. The serum of members of the second group (group II) can agglutinate the cells of persons belonging to the third and fourth groups, but not of other mem- bers of the second group itself nor, of course, of group I. The cells of mem- * Received for publication, February 5, 1911. This study is one of a pro- jected series on isoagglutination, which in turn constitutes a section of a com- prehensive plan of research on the composition of protoplasm as well as the structural and dynamic relationships of cell constituents and products. These investigations are now in progress in the Laboratory of Biological Chemistry of Columbia University, at the College of Physicians and Surgeons, and under the auspices of the George Crocker Special Research Fund. 425