Immunology Notebook: 2

Notebook filled by Alan Williams with workings, notes and comments on his Immunology work. Notes relate to affinity labelling of Immunoglobulin receptors on lymphocytes including, Serology of NIP and Nitrohydroxyiodophenylacetate and light-activated Nitrohydroxyiodophenylacetate, as haptens, Anti-Nitrohydroxyiodophenylacetate transfers, NIP-CG binding to cells (Chicken gammaglobulin, a standard “carrier” protein), and Anti-CG plaques.

The first mention of detection of radioactively-tagged antibody or hapten on single lymphocytes rather than on bulk populations of lymphocytes. Autoradiography of lymphocytes was a well-established technique in the Gowans lab at that time.

First mention of an attempt to delete NAP-specific B cells, as an experimental model of hapten-specific immunological tolerance in adoptive transfer of immunological memory. The Porter lab was heavily influenced by the successful [partial] “deletion” of specific clones on antigen-specific bead columns (Wigzell and Andersson, 1969).

11 June 1970-16 February 1971

1 volume

There are 59 notebooks detailing Alan Williams immunology research including notes on Thy-1 and 4 notebooks that focus on specific subjects including a book of methodologies and books on Nucleic Acid Chemistry and Monoclonals. The Notebooks 1 to 59 including a linking system that Alan used to call back to previous notes: where research or points from a previous book were furthered or expanded upon, Williams linked to them. The new information will have the number of the notebook containing the linked material, in a circle, and then sometimes a page number. These instances have not been detailed in the catalogue description as they are sometimes too numerous to be coherant without seeing the notebook.