Derivatives of glyoxaline-or 4(or 5)-formaldehyde and glyoxaline-4(or 5)-carboxylic acid : a new synthesis of histidine / Frank Lee Pyman.

  • Pyman, Frank Lee.
Date:
[1916?]
Catalogue details

Licence: In copyright

Credit: Derivatives of glyoxaline-or 4(or 5)-formaldehyde and glyoxaline-4(or 5)-carboxylic acid : a new synthesis of histidine / Frank Lee Pyman. Source: Wellcome Collection.

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    XXII. Derivatives of GlyoxalineA{or 5)-formaldehyde and Glyoxaline-i(or 5)-carboxylic Acid. A Neiv Synthesis of Histidine. By Frank Lee Pyman. Some of the simpler substituted glyoxalines are little known. The simplest aldehyde in this field, glyoxaline-4(or 5)-formaldehyde (II), was obtained by the author (T., 1912, 101, 542) in a yield of 15 per cent, of the theoretical by the oxidation of 4(or 5)-hydr- oxymethylglyoxaline (I) by means of chromic acid. As the analogue of benzaldehyde, the starting material for many syntheses in the aromatic series, this substance is of some importance. Its preparation and some of its reactions have therefore been studied. Glyoxalineformaldehyde may be obtained in a yield of more than 50 per cent, of the theoretical by the oxidation of hydroxy- methylglyoxaline with little more than the calculated quantity of nitric acid, and its stability towards oxidising agents is such that it is obtained in a small yield, together with large quantities of glyoxaline-4(or 5)-carboxylic acid (III), when the alcohol is oxidised with a very large excess of nitric acid over the quantity required for its conversion into the acid.