The alkaloids of ipecacuanha. Pt. 2 / by Frank Lee Pyman.

  • Pyman, Frank Lee.
Date:
1917.]
Catalogue details

Licence: Public Domain Mark

Credit: The alkaloids of ipecacuanha. Pt. 2 / by Frank Lee Pyman. Source: Wellcome Collection.

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    XXXVIil. — The Alkaloids of Ipecacuanha. Part II. By Frank Lee Pyman. The first part of this investigation (Carr and Pyman, P., 1913, 29, 226; T., 1914, 105, 1591) characterised the then known alkaloids of ipecacuanha—emetine, cephaeline, and psychotrine— and explained their mutual relations. Psychotrine was shown to have the formula C28H3604N2, and to yield on reduction a mixture of cephaeline and isocephaeline, both of which had the formula CsaHssO^. Emetine proved to be the monomethyl ether of cephaeline, and had the formula C29H40O4N2. Several crystalline derivatives of these alkaloids were described, and it was also shown that emetine gave on oxidation 6:7-dimethoxywoquinoline-l- carboxylic acid, whence it followed that these three alkaloids belong to the large class of naturally occurring bases derived from fsoquinoline.* * After the above paper had been written, but before its publication in the Transactions, O. Hesse (Annalen, 1914, 405, 1) recorded the results of an investigation on the same subject, and these were briefly discussed in an addendum to the first part of this research (loc. cit., p. 1637). Hesse con¬ firmed the formula C28H3P04N2 which he had previously (Phartn. J., 1898,