On the coagulation of the blood / by L.C. Wooldridge.

  • Wooldridge, Leonard Charles, 1857-1889.
Date:
[1883]
Catalogue details

Licence: Public Domain Mark

Credit: On the coagulation of the blood / by L.C. Wooldridge. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

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    ON THE COAGULATION OF THE BLOOD. By L. C. WOOLDEIDGE, D.Sc, M.B., George Henry Lewes Student The following communication is a continuation of the results already published by myself as to the influence of lecithin in producing coagula- tion of the blood \ The plasma used in those experiments was peptone plasma. In the present case I have made use of blood which has been prevented from coagulating by being, immediately after leaving the body, cooled down to a temperature of about 0^ For experiments on cooled plasma it is best to use the blood of the horse. I was however unable to obtain any horse's blood and therefore employed dog's blood. In horse's blood the corpuscles sink rapidly and the coagulation is very tardy, it is hence easy to obtain plasma. This is not the case with the dog, and I was therefore led to adopt a particular method of experimenting. The coagulation of the blood is brought about by a certain interaction of the white corpuscles and the plasma. By rapid cooling this interaction is to a great extent suppressed and hence the blood does not coagulate. But if one of the substances of which the white cells are made up be diffused through the cooled blood, coagulation does occur. This substance is lecithin. The method of experimenting is as follows. The blood is taken from a large artery and flows into a thin cylindrical metal vessel of about ■|-inch diameter. This tube stands in a large vessel filled with broken ice and a small quantity of water to fill up the interspaces. For each experiment two such tubes are used. Each holds 40 c.c. In the one is contained 15 c.c. of '6 per cent. NaCl solution, in the other a similar quantity of normal salt solution through which finely emulsified lecithin is diffused. The blood flows directly from the artery into the metal vessels, one 1 Further Observations on the Coagulation of Blood. Journal of Phijsiology, Vol. IV. Nos. 2 & 3. Zur Gerinnung des Blutes. ArcMv fur Anat. u. Physiol. 1883.