Notebook 4

Date:
20 February 1950 - 25 May 1950
Reference:
PP/GRW/A/3
Part of:
Wyatt, Gerard R. (1925-)
  • Archives and manuscripts
  • Online

Available online

view Notebook 4

Contains: 81 images

Attribution 4.0 International (CC BY 4.0)

You can use this work for any purpose, including commercial uses, without restriction under copyright law. You should also provide attribution to the original work, source and licence. Read more about this licence.

Credit

Notebook 4. Attribution 4.0 International (CC BY 4.0). Source: Wellcome Collection.

About this work

Description

Dr. Wyatt's second notebook to be titled Nucleic Acids, written during his time at the Virus Research Unit, Molteno Institue, Cambridge, England. Within this notebook are Dr. Wyatt's procedures and calculations to estimate the mean ratios of bases in the nucleic acids of ram sperm and calf thymus. The book contains the ultra violet spectra of the proposed methylcytosine extracted from nucleic acids of herring and ram sperm and a comparison of this data is made with UV spectra of synthetic 5-methylcytosine obtained from Mr. A. Pircio of Fordham University. This data provides the evidence for Dr. Wyatt's1950 Nature paper on the "Occurrence of 5-Methyl-Cytosine in Nucleic Acids". Also in this book are notes on Dr. Wyatt's experiments on samples of DNA from earthworms, yeast, locusts, mushrooms, echinoderms and moths. The back of the book contains standard absorption data for use with UV spectra.

Publication/Creation

20 February 1950 - 25 May 1950

Physical description

1 notebook Bound laboratory notebook containing 1 loose insert at the back titled Plant Viruses and a bookmark from Heffer's bookshop, Cambridge.

Arrangement

Experiments are recorded in chronological order from front to back with additional notes, procedures and data in the back pages.

Related material

Within this collection: PP/GRW/A/2; PP/GRW/B/1- Dr. G.R.Wyatt's papers labelled 273-277; PP/GRW/B/7 - Dr. G.R. Wyatt's chromatogram prints showing the extra spot of 5-methylcytosine; PP/GRW/B/8

Location of duplicates

A digitised copy is held by Wellcome Collection as part of Codebreakers: Makers of Modern Genetics.

Languages

Where to find it

  • LocationStatusAccess
    Closed stores

Permanent link