Aromatic esters of acylecgonines / by William Herbert Gray.

  • Gray, William Herbert.
Date:
[1925?]
Catalogue details

Licence: In copyright

Credit: Aromatic esters of acylecgonines / by William Herbert Gray. Source: Wellcome Collection.

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    Volume 127, 1925. lO CLX.—Aromatic Esters of Acylecgonines. By William Herbert Gray. mturally-occurring cocaine has served in several ways as a ftrting point in the search for the ideal local anaesthetic of low Ixicity. The characteristics of its structure essential to the velopment of pronounced anaesthetic action are now recognised be the amino- and acylated alcohol groups (I). A large variety aminoalkyl esters, not containing the bridged ring of cocaine, ,s been synthesised and some of these, including “ novocaine,55 stovaine,55 and 44 (3-eucaine,55 are in common use. In them, •wever, the power of penetrating mucous membrane possessed cocaine, which, for example, renders it so valuable in causing meal anaesthesia, is but feebly developed. In another scheme, the tropane skeleton has been retained and e effect of variation of the ester groups investigated. Substitution any other acyl radical for the benzoyl group very greatly diminishes e anaesthetic action, but the O-methyl group may give place to ^her aliphatic homologues, yielding substances with the typical operties of cocaine (Merck, Ber.t 1885, 18, 2954; Novv, Amer. wm. J.,1888, 10, 147):