Reprints 51-55

Date:
1963-1964
Reference:
PP/CRI/M/1/2
Catalogue details

Licence: In copyright

Credit: Reprints 51-55. Source: Wellcome Collection.

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    7 7 tfL&W? few«. *sv |P«0^£SS IN nS^S^RBEARCH, VOUI : ACADEMIC PRESS. INC., NEW. YORK, N,Y, V ' • The Recent Excitement ¡n the Coding Problem F. H. C. ORICK . F. H. C. C hick. Medical Research Council Laboratory of Molecular Biology Cambridge, England L Introduction 164 A. The Nature of the Problem 164 B. The Mechanism of Protein Synthesis 164 C. The Standard Bases and Amino Acids.' . . - 165 D. Glossary of Terms 166 II. General Questions 168 A. Is the Code Overlapping? _ • • .168 B. Is the Message Read from One End? • ••• - .170 C. The Coding Ratio and the Size of the Codon .... 172 D. Is the Code Universal? I? 3 .... - ï . in. The Cell-Free System 175 . C-u<sjj£f* A. Experimental Results and Interpretations 175 -, ; : B. Criticisms of the Experiments . • ' 7Í' C. Criticisms of the Interpretation 181 . D. On Random Sequences I® 2 , E. The Ochoa Triplets Assessed 183 . F. Polynucleotides Containing Unusual Bases . . . • 184 G. Summary . ' IV. Amino Acid Changes from a Single Mutation ..... 186 A. Experimental Data I® 7 B. Mutagenic Patterns ^ C. Interpretation 192 V. Further Experimental Evidence 1®^ A. Over-all Composition of Protein and DNA I 94 B. The Fractionation of eRNA I 9 ** C. The RNA of the Ribosomes . . • • ■ • . .19! D. Genetic Information • . ' ' . . 197 AT. Is the Code Degenerate? A. The Experimental Evidence . B. Possible Types of Degeneracy ^ C. Degeneracy and the bRNA D. Summary VII. Theoretical Matters . . . ... - ^ A. The Order of Bases within a Codon . . . - • • • 203