On transplantation of tumors / by Leo Loeb.

  • Loeb, Leo, 1869-1959.
Date:
[1903]
Catalogue details

Licence: In copyright

Credit: On transplantation of tumors / by Leo Loeb. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

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    | Reprinted from Ameri ON * LEO LOEB, M.D., of Montreal, Can. From the J. H. R. Molson Laboratories of Pathology and Bacteriology, McGill University, Montreal. 1.—ON THE RESISTING POWER OF EXCISED PIECES OF TUMORS. In several former communications I reported the results of a series of transplantations of a cystic sarcoma and of a mixed tumor, a sarcocarcinoma of the thyroid.* 2 In these investigations I used the method of transplan- tation (1) to determine experimentally the conditions of growth of tumors, and (2) to approach certain questions of the structure of tumors. I also reported some experi- ments in which I tried to determine the resisting power of excised pieces of tumors to unfavorable conditions. Since then these latter experiments have been con- tinued and I now wish to report upon the results obtained, mentioning also some previous observations. In these experiments I used in part tumors derived from the sarcomatous part of the mixed tumor of the thyroid; mainly, however, tumors derived from a third sarcoma of the thyroid of a rat, which was cystic, like the first sarcoma.3 I. Experiments to Produce Tumors by Transplanting Excised Pieces of the Sarcoma which had Previously Been Kept at a Temperature of 3° C. to If C.—After I had succeed- ed in successfully transplanting pieces of tumor, which after the death of the animal had been kept at room temperature for 12 hours, I further extended the time of keeping the tumor outside of the living animal before transplanting it. Pieces of a large tumor, which was infected in the ■A somewhat fuller report will appear later. 2 (a) On Transplantation of Tumors, Journ. Med. Research, n. s. Voi. i, No. 1, 1902. (6) Uber Transplantationen eines Sarcoma de Ihyreoidea beieiner weissen Ratte, Virchow’s Archiv. Vol clxvii. (c) Further Investigations in Transplantation of Tumors, Journ. Med. Research, Vol. iii, 1902. r JII.am indebted for this tumor to the kindness of Professor Herzog, cag2- The experimental part of this work was partly done In the Gratwich Research Laboratory of Buffalo in the«unmerof 1902.