Hæmatoporphyminuria and its relations to the source of urobilin / by David Fraser Harris.

  • Fraser-Harris, David Fraser, 1867-1937.
Date:
[1898]
Catalogue details

Licence: Public Domain Mark

Credit: Hæmatoporphyminuria and its relations to the source of urobilin / by David Fraser Harris. Source: Wellcome Collection.

Provider: This material has been provided by The University of Glasgow Library. The original may be consulted at The University of Glasgow Library.

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    H^MATOPOEPHYfrlNUEIA AND ITS RELATIONS TO THE SOUECE OF UEOBILIN. By David Eraser Harris, B.Sc. (Lond)., M.B., CM., F.B.S.E., Muirhead Demonstrator of Physiology in the University of Glasgow. I would first of all like to allude to a case of abnormally pigmented urine, which I had the privilege of examining through the kindness of Professor M'Call Anderson, University of Glasgow.1 It was one of those very rare cases of ' burgundy-red' urine similar to two examined by M'Munn, and published by Eanking and Pardington {Lancet, 1890, vol. ii. p. 607). The pigment here and in Professor M'Call Anderson's case— one of dermatitis hfpetiformis bullosa—was not uro-hsemato- porphyrin, but a closely allied body, believed by M'Munn to be less de-oxidised than uro-hsematoporphyrin, or than urobilin. M'Munn has not named it; and as it is awkward to have to allude to it always by a periphrase, I suggest that it be known as Meio-de-oxy-hazmatoporphyrin. The urine in the case I examined was claret-coloured, did not give the guaiac reaction, did not contain biliary pigment, nor any proteid. With the spectroscope it showed very distinctly a four-banded absorption spectrum, closely resembling that of uro-haematoporphyrin, with one band in the red, two between D and E lines, and one band near the F line. Such a reducing substance as ammonium sulphide had no effect whatever on the pigment, which, had it been met- hsemoglobin—a vastly commoner four-banded pigment—would have been reduced through oxy-hsemoglobin to haemoglobin; but treatment with concentrated sulphuric acid instantly gave rise to a pigment with the characteristic double-banded absorp- tion spectrum of acid-haematoporphyrin. On careful spectroscopic examination there was no possibility of confusing this rare pigment with met-haemoglobin, as in the 1 The case is published in the Scottish Medical and Surgical Journal, February 1897. (Jack and Borland on a case of Hoematoporphyrinuria).