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  • Solanum atropurpureum Schrank Solanaceae. Purple Devil. Purple-spined Nightshade. Herbaceous perennial. Distribution: Brazil. This ferociously spined plant contains tropane alkaloids, atropine, hyoscyamine and scopolamine. All are anticholinergic and block the acetylcholine mediated actions of the parasympathetic nervous system. While the alkaloids are used in medicine and as an antidote to anticholinergic nerve gas poisons, the plant itself is not used in medicine. Its sharp spines can be irritant. Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • Senecio pulcher Hook.&Arn. Asteraceae Distribution: South America. It has not attracted attention as a medicinal or toxic plant but members of the genus Senecio contain pyrrolizidine alkaloids that are toxic to the liver and may cause liver cancer. A traditional Chinese medicine (TCM) product, Qianbai Biyan Pian, contains Senecio scandens which contains the unsaturated pyrrolizidine alkaloids, senecionine and seneciphylline. This is now a banned drug. (Safety of Herbal Medicinal Products, July 2002, Medicines Control Agency). Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • Senecio pulcher Hook.&Arn. Asteraceae Distribution: South America. It has not attracted attention as a medicinal or toxic plant but members of the genus Senecio contain pyrrolizidine alkaloids that are toxic to the liver and may cause liver cancer. A traditional Chinese medicine (TCM) product, Qianbai Biyan Pian, contains Senecio scandens which contains the unsaturated pyrrolizidine alkaloids, senecionine and seneciphylline. This is now a banned drug. (Safety of Herbal Medicinal Products, July 2002, Medicines Control Agency). Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • Petasites paradoxus Baumg. Asteraceae Alpine Butterbur. Herbaceous Perennial. Distribution: Temperate Northern hemisphere. It contains pyrrolizidine alkaloids, which are hepatotoxic and cause liver cancers. Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • Eschscholzia californica Cham. Papaveraceae. Californian poppy. Named for German botanist and physician, Johan Friedrich von Eschscholtz (1793-1831). Distribution: North America. Official state flower of California. Contains berberine, considered a potential source for many new medicines, and numerous alkaloids some of which may have mild anxiolytic activity. Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • Cynoglossum officinale L. Boraginaceae. Houndstongue. Distribution: Europe. Culpeper (1650) writes: “... being roasted and laid to the fundament, helps the haemorrhoids. It is also good against burnings and scaldings.” It contains hepatocarcinogenic pyrrolizidine alkaloids and while people are known to eat the young leaves as a vegetable, this is inadvisable. The whole plant is hairy and may cause contact dermatitis. The use of herbal remedies, which contain these alkaloids, by the Bantu of southern Africa correlates with their high incidence of tumours of the liver and pancreas. Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • Petasites hybridus (L.)G.Gaertn., B.Mey. & Scherb. Asteraceae. Butterbur, Bog rhubarb. Distribution: Europe, NW Asia. Culpeper (1650) writes: “The roots are ... exceeding good in violent and pestilential fevers, they provoke the terms, expel poison, and kill worms.” Modern herbalists recommend it for a wide range of therapies, but it contains pyrrolizidine alkaloids, which are hepatotoxic and cause liver cancers. Nevertheless, in a trial aimed at reducing frequency of migraine attacks, a standardised commercial preparation was well tolerated, and was effective at higher doses, but placebo in this trial reduced migraines by over 50% in 49% of the patients (Neurology 2004
  • Petasites hybridus (L.)G.Gaertn., B.Mey. & Scherb. Asteraceae. Butterbur, Bog rhubarb. Distribution: Europe, NW Asia. Culpeper (1650) writes: “The roots are ... exceeding good in violent and pestilential fevers, they provoke the terms, expel poison, and kill worms.” Modern herbalists recommend it for a wide range of therapies, but it contains pyrrolizidine alkaloids, which are hepatotoxic and cause liver cancers. Nevertheless, in a trial aimed at reducing frequency of migraine attacks, a standardised commercial preparation was well tolerated, and was effective at higher doses, but placebo in this trial reduced migraines by over 50% in 49% of the patients (Neurology 2004
  • Allium schoenoprasum L. Alliaceae. Chives. Bulbour perennial herb. 'schoenoprasm' means 'rush leek' in Greek, referring to the narrow leaves. Distribution: Asia, Europe and North America. Leaves used as a garnish on cooked food and in salads. However like others in Boraginaceae it contains the pyrrolizidine alkaloid cynoglossine which causes liver damage. Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • Tussilago farfara L. Asteraceae. Coltsfoot. Distribution: Europe, N. Africa, W & N Asia . Culpeper (1650) writes: ‘Tussilago. Coltsfoot. ... they are admirable good for coughs and consumptions of the lungs, shortness of breath etc. It is often used and with great success taken in a tobacco pipe, being cut and mixed with a little oil of Annis seeds.’ It is hepatotoxic genotoxic and carcinogenic due to the pyrrolizidine alkaloids that it contains. It should not be taken internally (Medicines Control Agency, 2002). Photographed in the Medicinal Garden of the Royal College of Physicians, London.