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Veratrum album L. Melanthiaceae Distribution: Europe. Cows do not eat Veratrum species in the meadows, and human poisoning with it caused vomiting and fainting. In the 1850s it was found to reduce the heart's action and slow the pulse (Bentley, 1861, called it an 'arterial sedative'), and in 1859 it was used orally in a woman who was having convulsions due to eclampsia. Dr Paul DeLacy Baker in Alabama treated her with drops of a tincture of V. viride. She recovered. It was used thereafter, as the first choice of treatment, and when blood pressure monitoring became possible, it was discovered that it worked by reducing the high blood pressure that occurs in eclampsia. By 1947 death rates were reduced from 30% to 5% by its use at the Boston Lying in Hospital. It works by dilating the arteries in muscles and in the gastrointestinal circulation. A further use of Veratrum species came to light when it was noted that V. californicum -and other species - if eaten by sheep resulted in foetal malformations, in particular only having one eye. The chemical in the plant that was responsible, cyclopamine, was found to act on certain genetic pathways responsible for stem cell division in the regulation of the development of bilateral symmetry in the embryo/foetus. Synthetic analogues have been developed which act on what have come to be called the 'hedgehog signalling pathways' in stem cell division, and these 'Hedgehog inhibitors' are being introduced into medicine for the treatment of various cancers like chondrosarcoma, myelofibrosis, and advanced basal cell carcinoma. The drugs are saridegib, erismodegib and vismodegib. All the early herbals report on its ability to cause vomiting. As a herbal medicine it is Prescription Only, via a registered dentist or physician (UK Medicines and Healthcare Products Regulatory Agency (MHRA)). Photographed in the Medicinal Garden of the Royal College of Physicians, London.
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Veratrum nigrum L. Melanthiaceae Distribution: Europe. Cows do not eat Veratrum species in the meadows, and human poisoning with it caused vomiting and fainting. In the 1850s it was found to reduce the heart's action and slow the pulse (Bentley, 1861, called it an 'arterial sedative'), and in 1859 it was used orally in a woman who was having convulsions due to eclampsia. Dr Paul DeLacy Baker in Alabama treated her with drops of a tincture of V. viride. She recovered. It was used thereafter, as the first choice of treatment, and, when blood pressure monitoring became possible, it was discovered that it worked by reducing the high blood pressure that occurs in eclampsia. By 1947 death rates were reduced from 30% to 5% by its use at the Boston Lying-in Hospital. It works by dilating the arteries in muscles and in the gastrointestinal circulation. A further use of Veratrum species came to light when it was noted that V. californicum - and other species - if eaten by sheep resulted in foetal malformations, in particular only having one eye. The chemical in the plant that was responsible, cyclopamine, was found to act on certain genetic pathways responsible for stem cell division in the regulation of the development of bilateral symmetry in the embryo/foetus. Synthetic analogues have been developed which act on what have come to be called the 'hedgehog signalling pathways' in stem cell division, and these 'Hedgehog inhibitors' are being introduced into medicine for the treatment of various cancers like chondrosarcoma, myelofibrosis, and advanced basal cell carcinoma. The drugs are saridegib, erismodegib and vismodegib. All the early herbals report on its ability to cause vomiting. As a herbal medicine it is Prescription Only, via a registered dentist or physician (UK Medicines and Healthcare Products Regulatory Agency (MHRA)). Photographed in the Medicinal Garden of the Royal College of Physicians, London.
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Primula veris L. Primulaceae Cowslip, Herba paralysis Distribution: W. Asia, Europe. Fuchs ((1542) quotes Dioscorides Pliny and Galen, with numerous uses, from bruises, toothache, as a hair dye, for oedema, inflamed eye, and mixed with honey, wine or vinegar for ulcer and wounds, for scorpion bites, and pain in the sides and chest, and more. Lobel (1576) calls them Primula veriflorae, Phlomides, Primula veris, Verbascula. Lyte (1578) calls them Cowslippe, Petie mulleyn, Verbasculum odoratum, Primula veris, Herbae paralysis and Artheticae. Along with cowslips and oxeslips, he says they are 'used dayly among other pot herbes, but in Physicke there is no great account of them. They are good for the head and synewes ...'. Like other herbals of the 16th and 17th century, the woodcuts leave one in no doubt that Primula veris was being written about. However, other translators of Dioscorides (Gunther, 1959 with Goodyear's 1655 translation
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Paeonia suffruticosa 'Chang Zhi Hong'
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Rhamnus frangula 'Asplenifolia'
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Paeonia suffruticosa 'Bai Yu'
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Silybum marianum (L.) Gaertn. Asteraceae Milk thistle. Carduus Mariae. Distribution: Europe. Gerard (1633) calls it Carduus Mariae, Carduus Lectus, or Ladies Thistle, and Carduus leucographus [meaning 'white writing', in reference to the white markings on the leaves] because Pliny wrote about a plant he called Leucographis although Gerard notes that it would be 'hard to assume this to be the same [plant].' He also queries if it is the same as the Alba spina of Galen. Of the latter he reports that Galen recommended it for all manner of bleeding, toothache and the seeds for cramp. Gerard writes that Dioscorides recommends that a drink of the seeds helps infants whose sinews are 'drawne together'
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Paeonia suffruticosa 'Bai Yu'
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Mark Walport. Oil painting by Tess Barnes, 2011.
Barnes, Tess.Date: [2011]Reference: 825626i- Digital Images
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Primula veris L. Primulaceae. Cowslip, Herba paralysis Distribution: W. Asia, Europe. Fuchs ((1542) quotes Dioscorides Pliny and Galen, with numerous uses, from bruises, toothache, as a hair dye, for oedema, inflamed eye, and mixed with honey, wine or vinegar for ulcer and wounds, for scorpion bites, and pain in the sides and chest, and more. Lobel (1576) calls them Primula veriflorae, Phlomides, Primula veris, Verbascula. Like other herbals of the 16th and 17th century, the woodcuts leave one in no doubt that Primula veris was being written about. However, other translators of Dioscorides (Gunther, 1959 with Goodyear's 1655 translation
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Atropa belladonna L. Solanaceae. Deadly nightshade. Dwale. Morella, Solatrum, Hound's berries, Uva lupina, Cucubalus, Solanum lethale. Atropa derives from Atropos the oldest of the three Fates of Greek mythology who cut the thread of Life (her sisters Clotho and Lachesis spun and measured the thread, respectively). belladonna, literally, means 'beautiful lady' and was the Italian name for it. Folklore has it that Italian ladies put drops from the plant or the fruits in their eyes to make themselves doe-eyed, myopic and beautiful. However, this is not supported by the 16th and 17th century literature, where no mention is ever made of dilated pupils (or any of the effects of parasympathetic blockade). Tournefort (1719) says 'The Italians named this plant Belladonna, which in their language signifies a beautiful woman, because the ladies use it much in the composition of their Fucus [rouge or deceit or cosmetic] or face paint.' Parkinson says that the Italian ladies use the distilled juice as a fucus '... peradventure [perhaps] to take away their high colour and make them looke paler.' I think it more likely that they absorbed atropine through their skin and were slightly 'stoned' and disinhibited, which made them beautiful ladies in the eyes of Italian males. Distribution: Europe, North Africa, western Asia. Culpeper (1650) writes: 'Solanum. Nightshade: very cold and dry, binding … dangerous given inwardly … outwardly it helps the shingles, St Antonie's Fire [erysipelas] and other hot inflammation.' Most of the 16th, 17th and 18th century herbals recommend it topically for breast cancers. Poisonous plants were regarded as 'cold' plants as an excess of them caused death and the body became cold. They were regarded as opposing the hot humour which kept us warm and alive. Poultices of Belladonna leaves are still recommended for muscle strain in cyclists, by herbalists. Gerard (1633) writes that it: 'causeth sleep, troubleth the mind, bringeth madnesse if a few of the berries be inwardly taken, but if more be taken they also kill...'. He was also aware that the alkaloids could be absorbed through the skin for he notes that a poultice of the leaves applied to the forehead, induces sleep, and relieves headache. The whole plant contains the anticholinergic alkaloid atropine, which blocks the peripheral actions of acetylcholine in the parasympathetic nervous system. Atropine is a racemic mixture of d- and l- hyoscyamine. Atropine, dropped into the eyes, blocks the acetylcholine receptors of the pupil so it no longer constricts on exposure to bright light - so enabling an ophthalmologist to examine the retina with an ophthalmoscope. Atropine speeds up the heart rate, reduces salivation and sweating, reduces gut motility, inhibits the vertigo of sea sickness, and is used to block the acetylcholine receptors to prevent the effects of organophosphorous and other nerve gas poisons. It is still has important uses in medicine. Atropine poisoning takes three or for days to wear off, and the hallucinations experienced by its use are described as unpleasant. We have to be content with 'madness', 'frenzie' and 'idle and vain imaginations' in the early herbals to describe the hallucinations of atropine and related alkaloids as the word 'hallucination' in the sense of a perception for which there is no external stimulus, was not used in English until 1646 (Sir T. Browne, 1646). It is a restricted herbal medicine which can only be sold in premises which are registered pharmacies and by or under the supervision of a pharmacist (UK Medicines and Healthcare Products Regulatory Agency (MHRA)). Photographed in the Medicinal Garden of the Royal College of Physicians, London.
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Inula helenium L. Asteraceae. Elecampine, Elecampane, Enulae campinae Distribution: Britain, S. Europe to the Himalayas. Used medicinally for 2,000 years. Culpeper (1650) writes ‘Elecampane, is ... wholesome for the stomach, resists poison, helps old coughs and shortness of breath, helps ruptures and provokes lust
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Garden Room. Palliative care. NHS Trust, UK
Hedley Finn, The King's Fund, Wellcome Collection- Digital Images
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Vitex agnus-castus var. latifolia
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Ruscus aculeatus L. Ruscaceae Butchers Broom., Box holly, Knee Holly, Jew’s myrtle. Distribution: Mediterranean to Britain. Aculeatus means 'prickly' which describes the plant well. Dioscorides in 70 AD (Gunther, 1959) says of this plant ‘... ye leaves and berries drunk in wine have ye force to move urine, expel the menstrua, and to break ye stones in ye bladder ...’ and adds also ‘ ... it cures also ye Icterus and ye strangurie and ye headache.' Its use did not change for a millennium and a half
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Dimapur, a drug addict, debating on if he is HIV+ or not; an advertisement by Lifeline, NMA Kripa, Prodigal Home, and the State AIDS Office Nagaland. Colour lithograph, ca. 1997.
Date: [1997?]Reference: 677310i- Pictures
A wrought-iron bridge joining two sides of a rocky ravine; representing help to those needing transplanted organs. Colour lithograph, 199-.
Date: [between 1990 and 1999?]Reference: 729403i