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Veratrum album L. Melanthiaceae Distribution: Europe. Cows do not eat Veratrum species in the meadows, and human poisoning with it caused vomiting and fainting. In the 1850s it was found to reduce the heart's action and slow the pulse (Bentley, 1861, called it an 'arterial sedative'), and in 1859 it was used orally in a woman who was having convulsions due to eclampsia. Dr Paul DeLacy Baker in Alabama treated her with drops of a tincture of V. viride. She recovered. It was used thereafter, as the first choice of treatment, and when blood pressure monitoring became possible, it was discovered that it worked by reducing the high blood pressure that occurs in eclampsia. By 1947 death rates were reduced from 30% to 5% by its use at the Boston Lying in Hospital. It works by dilating the arteries in muscles and in the gastrointestinal circulation. A further use of Veratrum species came to light when it was noted that V. californicum -and other species - if eaten by sheep resulted in foetal malformations, in particular only having one eye. The chemical in the plant that was responsible, cyclopamine, was found to act on certain genetic pathways responsible for stem cell division in the regulation of the development of bilateral symmetry in the embryo/foetus. Synthetic analogues have been developed which act on what have come to be called the 'hedgehog signalling pathways' in stem cell division, and these 'Hedgehog inhibitors' are being introduced into medicine for the treatment of various cancers like chondrosarcoma, myelofibrosis, and advanced basal cell carcinoma. The drugs are saridegib, erismodegib and vismodegib. All the early herbals report on its ability to cause vomiting. As a herbal medicine it is Prescription Only, via a registered dentist or physician (UK Medicines and Healthcare Products Regulatory Agency (MHRA)). Photographed in the Medicinal Garden of the Royal College of Physicians, London.
Dr Henry Oakeley- Books
ACT for gender identity : the comprehensive guide / Alex Stitt.
Stitt, Alex L.Date: 2020- Archives and manuscripts
Tavistock Centre for Couple Relationships
Family Welfare AssociationDate: 1920s-2000sReference: SA/TCC- Books
- Online
Working in a world of hurt : trauma and resilience in the narratives of medical personnel in warzones / Carol Acton and Jane Potter.
Acton, Carol, 1958-Date: 2015- Books
Matrescence : on the metamorphosis of pregnancy, childbirth and motherhood / Lucy Jones.
Jones, Lucy (Journalist)Date: 2023- Books
Growing inwards and outwards without a clear pattern by Aitor Gonzalez.
Gonzalez, AitorDate: [2022]- Archives and manuscripts
Society of Medical Officers of Health
Society of Medical Officers of HealthDate: 1856-1998Reference: SA/SMO- Archives and manuscripts
Sir John Hall (1795-1866), military surgeon
Hall, John, Sir.Date: 1843-1859Reference: MS.8520- Books
Handbook of adult resilience / edited by John W. Reich, Alex J. Zautra, John Stuart Hall.
Date: [2010]- Books
Louder than words : the new science of how the mind makes meaning / Benjamin K. Bergen.
Bergen, Benjamin K.Date: 2012- Archives and manuscripts
English Language Autograph Letters: GO
Date: 1680-1922Reference: MS.9142- Archives and manuscripts
Joseph Conrad (1857-1924), novelist: notes on his health
Curle, Richard, 1883-1968.Date: 1936Reference: MS.8512- Videos
The dark matter of love.
Date: 2013- Books
The Oxford handbook of music and the brain / edited by Michael H. Thaut and Donald A. Hodges.
Date: 2019- Archives and manuscripts
Queen's Nursing Institute
Queen's Nursing InstituteDate: 1887-1997Reference: SA/QNI- Audio
The history of legal medicine in Britain and Europe.
Date: 9-11 April, 1987- Books
Women in the history of science : a sourcebook / edited by Hannah Wills, Sadie Harrison, Erika Jones, Farrah Lawrence-Mackey and Rebecca Martin.
Date: 2023- Videos
Medicine through time.
Date: 1998- Archives and manuscripts
Medical miscellany
Fretchwell, Nathaniell, fl. 1674, of St Clement Danes, Middlesex, apothecaryDate: 1662-1907Reference: MS.9276- Archives and manuscripts
Murchison, Sir Roderick Impey (1792-1871), President of the Geological Society and the Royal Geographical Society
Sir Roderick Impey Murchison, 1792-1871, President of the Geological Society and the Royal Geographical SocietyDate: 1815-1871Reference: MS.5220