Molecular approaches to the therapy of HIV infection : a residential meeting at Robinson College, Cambridge : Monday - Wednesday 9-11 July 1990 / convened by Dr. B.C.L. Walker for The Society for Drug Research.

Veratrum nigrum L. Melanthiaceae Distribution: Europe. Cows do not eat Veratrum species in the meadows, and human poisoning with it caused vomiting and fainting. In the 1850s it was found to reduce the heart's action and slow the pulse (Bentley, 1861, called it an 'arterial sedative'), and in 1859 it was used orally in a woman who was having convulsions due to eclampsia. Dr Paul DeLacy Baker in Alabama treated her with drops of a tincture of V. viride. She recovered. It was used thereafter, as the first choice of treatment, and, when blood pressure monitoring became possible, it was discovered that it worked by reducing the high blood pressure that occurs in eclampsia. By 1947 death rates were reduced from 30% to 5% by its use at the Boston Lying-in Hospital. It works by dilating the arteries in muscles and in the gastrointestinal circulation. A further use of Veratrum species came to light when it was noted that V. californicum - and other species - if eaten by sheep resulted in foetal malformations, in particular only having one eye. The chemical in the plant that was responsible, cyclopamine, was found to act on certain genetic pathways responsible for stem cell division in the regulation of the development of bilateral symmetry in the embryo/foetus. Synthetic analogues have been developed which act on what have come to be called the 'hedgehog signalling pathways' in stem cell division, and these 'Hedgehog inhibitors' are being introduced into medicine for the treatment of various cancers like chondrosarcoma, myelofibrosis, and advanced basal cell carcinoma. The drugs are saridegib, erismodegib and vismodegib. All the early herbals report on its ability to cause vomiting. As a herbal medicine it is Prescription Only, via a registered dentist or physician (UK Medicines and Healthcare Products Regulatory Agency (MHRA)). Photographed in the Medicinal Garden of the Royal College of Physicians, London.

Veratrum album L. Melanthiaceae Distribution: Europe. Cows do not eat Veratrum species in the meadows, and human poisoning with it caused vomiting and fainting. In the 1850s it was found to reduce the heart's action and slow the pulse (Bentley, 1861, called it an 'arterial sedative'), and in 1859 it was used orally in a woman who was having convulsions due to eclampsia. Dr Paul DeLacy Baker in Alabama treated her with drops of a tincture of V. viride. She recovered. It was used thereafter, as the first choice of treatment, and when blood pressure monitoring became possible, it was discovered that it worked by reducing the high blood pressure that occurs in eclampsia. By 1947 death rates were reduced from 30% to 5% by its use at the Boston Lying in Hospital. It works by dilating the arteries in muscles and in the gastrointestinal circulation. A further use of Veratrum species came to light when it was noted that V. californicum -and other species - if eaten by sheep resulted in foetal malformations, in particular only having one eye. The chemical in the plant that was responsible, cyclopamine, was found to act on certain genetic pathways responsible for stem cell division in the regulation of the development of bilateral symmetry in the embryo/foetus. Synthetic analogues have been developed which act on what have come to be called the 'hedgehog signalling pathways' in stem cell division, and these 'Hedgehog inhibitors' are being introduced into medicine for the treatment of various cancers like chondrosarcoma, myelofibrosis, and advanced basal cell carcinoma. The drugs are saridegib, erismodegib and vismodegib. All the early herbals report on its ability to cause vomiting. As a herbal medicine it is Prescription Only, via a registered dentist or physician (UK Medicines and Healthcare Products Regulatory Agency (MHRA)). Photographed in the Medicinal Garden of the Royal College of Physicians, London.

Nautisan : bei nervösem Erbrechen der Säuglinge, Pertussis, Chorea, azetonämischem Erbrechen usw.

Usos aceptados por el consejo de quimica y farmacia de la Asociación Medica Americana de la Dramamine ... / G.D. Searle & Co. ; distribuído por: Enrique Ferreyros y Cia., S.A.

Plegicil : neurolplégico : gran actividad, dosis terapeuticas bajas / Laboratoires Clin-Comar ; hecho en Mexico por: Labfarmex, S.A.

Neuroplagico Largactil : lo que hay que saber del: Largactil ... / marcas Rhône Poulenc Specia.

Neuropléjico Largactil : lo que es preciso saber del: Largactil ... / Société parisienne d'expansion chimique.

En la arteriosclerosis, hipertonia, angina de pecho, y espasmos vasomotores, Iocapral vasorregulador : Luminal ... Luminal Sodico ... Luminaletas / Winthrop Products Inc.

Cuando el vómito es incontrolable prescriba Bonamina ... : Terramicina SF, Tetracyna SF ... suprime más rápidamente la infección, favorece la convalencia / Laboratorios Pfizer, S.A.

Suprime más rápidamente la infección, favorece la convalencia ...Terramicina SF, Tetracyna SF ... : Cuando el vómito es incontrolable prescriba Bonamina ... / Laboratorios Pfizer, S.A.

Leprosy: multidrug therapy

Drug advertising ephemera. Box 13.

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