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  • Inhibition of Ca emission by fibroblasts
  • Inhibition of CDK2 by staurosporine, model
  • Protein tyrosine phosphatase, inhibition
  • Protein tyrosine phosphatase, inhibition
  • Pancuronium inhibition of ACh receptorsn
  • Your key to promoting safer sex : Durex condom keyrings : the ideal way to remove inhibitions fom carrying condoms / LRC Products Limited.
  • Your key to promoting safer sex : Durex condom keyrings : the ideal way to remove inhibitions fom carrying condoms / LRC Products Limited.
  • Justicia carnea Lindl. Acanthaceae. Brazilian Plume flower, Flamingo flower. Shrimp plant. Tender shrub. Distribution: Atlantic coast of Brazil. Named for James Justice (1698-1753) Scottish horticulturist, lawyer, 'tulip maniac' (Desmond, 1977). Asian species of Justicia are noted to be toxic and contain cytotoxic compounds which inhibit virus replication (Wiart, 2006) Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • Colchicum autumnale L., Colchicaceae. Autumn crocus, meadow saffron, naked ladies. Distribution: Europe. Extremely toxic, containing colchicine which is effective in small doses in treating gout. It inhibits mitosis so is of interest in cancer treatment. It is used to treat Familial Mediterranean fever. It induces polyploidy in plant protocorms for the production of tetraploid forms which have bigger flowers and seeds. Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • Erythroxylum coca Lam. Erythroxylaceae Coca. Distribution: Peru . Cocaine is extracted from the leaf. It is no longer in the UK Pharmacopoeia (used to be used as a euphoriant in ‘Brompton Mixture’ for terminally ill patients). Cocaine, widely used as a local anaesthetic until 1903, inhibits re-uptake of dopamine and serotonin at brain synapses so these mood elevating chemicals build up and cause a ‘high’. Its use was often fatal. Coca leaf chewing was described by Nicolas Monardes (1569
  • Iris unguicularis Poir. Iridaceae. Algerian iris. Rhizomatous perennial. Distribution: NW Africa, E. Mediterranean It has scientifically-based potential. The rhizomes contain the chemical kaempferol which inhibits the enzyme alpha-glucosidase in the gut, reducing the rate of glucose absorption. This could be used to prevent the dangerous peaks of blood sugar that occur in diabetics and reduce eye and kidney complications. The unprocessed rhizome contains iridin, a toxic glycoside, which causes 'nausea, vomiting, diarrhoea and skin irritation'. Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • Galega officinalis L. Fabaceae. Goat's Rue. Distribution: Central and Southern Europe, Asia Minor. Culpeper (1650) writes that it ‘... resists poison, kills worms, resists the falling sickness [epilepsy], resisteth the pestilence.’ Galega officinalis contains guanidine which reduces blood sugar by decreasing insulin resistance and inhibiting hepatic gluconeogenesis.. Metformin and Phenformin are drugs for type II diabetes that rely on this group of chemicals, known as biguanidines. Its name gala, meaning milk plus ega meaning 'to bring on', refers to its alleged property of increasing milk yield, and has been used in France to increase milk yield in cows. officinalis refers to its use in the offices of the monks, and is a common specific name for medicinal plants before 1600 and adopted by Linnaeus (1753). The fresh plant tastes of pea pods. Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • Silphium perfoliatum L. Asteraceae Indian Cup. Distribution: North America. Austin (2004) records that another species, S. compositum, was used by Native Americans to produce a chewing gum from the dried sap of the roots, and Native American medicinal uses for 'Indian Cup' are probably referrable to S. compositum and not S. perfoliatum. Silphium perfoliatum contains enzymes that inhibit trypsin and chymotrypsin which gives it resistance to fungal, bacterial and insect attacks. Male gall wasps (Antisotrophus rufus) alter the chemistry of the plant to enable them to locate females, making it a 'signpost' plant. The gall wasp lays its eggs in the stem of Silphium laciniatum, to provide food for the larva on emergence, and the galls containing a male or a female wasp will cause the plant to give off a different chemical odour. Emerging male wasps can search for female wasps, which emerge later, by locating this chemical fragrance which acts as a sex pheromone proxy (Tooker et al Proc Natl Acad Sci U S A. 2002 Nov 26
  • Cistus incanus ssp creticus Juss. Cistaceae. Rock Rose. Distribution: Crete. Interesting symbiosis with fungus called Tuber melanosporum which increases nutrient absorption for the plant and inhibits growth of other plants in the vicinity. It is a source of the resin ‘labdanum’ (a.k.a. ‘ladanum’) used in perfumes (similar smell to ambergris), as is Cistus ladanifer. It has no medical uses now, and such use was dwindling even in the 18th century. In the 16th century (Henry Lyte’s 1575 translation of Rembert Dodoen’s Cruydeboeck of 1554) its uses were described (directly copied from Dioscorides’ Materia Medica (70AD)) as: ‘Ladanum dronketh with olde wine, stoppeth the laske [periods], and provoketh urine. It is very good against the hardness of the matrix or mother [uterus] layde to in the manner of a pessarie, and it draweth down the secondes or afterbirth, when it is layde upon quicke coles [hot coals], and the fumigation or parfume thereof be received up into the body of women. // The same applied to the head with Myrrhe and oyle of Myrrhe, cureth the scurffe, called Alopecia, and keepeth the heare [hair] from falling of [sic], but whereas it is already fallen away, it will not cause the heare to growe agayne. // ...' and goes on in this vein about its uses for pain in the ears, and removing sores and scars and other things. Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • Taxus baccata L. Taxaceae European Yew. Trees are feminine in Latin, so while Taxus has a masculine ending (-us), its specific name, baccata (meaning 'having fleshy berries' (Stearn, 1994)), agrees with it in gender by having a female ending ( -a). Distribution: Europe. Although regarded as poisonous since Theophrastus, Gerard and his school friends used to eat the red berries (they are technically called 'arils') without harm. Johnson clearly ate the fleshy arils and spat out the seed, which is as poisonous as the leaves. It is a source of taxol, an important chemotherapeutic agent for breast and other cancers. It was first extracted from the bark of T. brevifolia, the Pacific yew tree, in 1966. About 1,100 kg of bark produces 10 g of taxol, and 360,000 trees a year would have been required for the needs of the USA – an unsustainable amount. In 1990 a precursor of taxol was extracted from the needles of the European yew so saving the Pacific trees. It is now produced in fermentation tanks from cell cultures of Taxus. Curiously, there is a fungus, Nodulisporium sylviforme, which lives on the yew tree, that also produces taxol. Because taxol stops cell division, it is also used in the stents that are inserted to keep coronary arteries open. Here it inhibits – in a different way, but like anti-fouling paint on the bottom of ships – the overgrowth of endothelial cells that would otherwise eventually block the tube. The economic costs of anticancer drugs are significant. Paclitaxel ‘Taxol’ for breast cancer costs (2012) £246 every 3 weeks
  • Atropa belladonna L. Solanaceae. Deadly nightshade. Dwale. Morella, Solatrum, Hound's berries, Uva lupina, Cucubalus, Solanum lethale. Atropa derives from Atropos the oldest of the three Fates of Greek mythology who cut the thread of Life (her sisters Clotho and Lachesis spun and measured the thread, respectively). belladonna, literally, means 'beautiful lady' and was the Italian name for it. Folklore has it that Italian ladies put drops from the plant or the fruits in their eyes to make themselves doe-eyed, myopic and beautiful. However, this is not supported by the 16th and 17th century literature, where no mention is ever made of dilated pupils (or any of the effects of parasympathetic blockade). Tournefort (1719) says 'The Italians named this plant Belladonna, which in their language signifies a beautiful woman, because the ladies use it much in the composition of their Fucus [rouge or deceit or cosmetic] or face paint.' Parkinson says that the Italian ladies use the distilled juice as a fucus '... peradventure [perhaps] to take away their high colour and make them looke paler.' I think it more likely that they absorbed atropine through their skin and were slightly 'stoned' and disinhibited, which made them beautiful ladies in the eyes of Italian males. Distribution: Europe, North Africa, western Asia. Culpeper (1650) writes: 'Solanum. Nightshade: very cold and dry, binding … dangerous given inwardly … outwardly it helps the shingles, St Antonie's Fire [erysipelas] and other hot inflammation.' Most of the 16th, 17th and 18th century herbals recommend it topically for breast cancers. Poisonous plants were regarded as 'cold' plants as an excess of them caused death and the body became cold. They were regarded as opposing the hot humour which kept us warm and alive. Poultices of Belladonna leaves are still recommended for muscle strain in cyclists, by herbalists. Gerard (1633) writes that it: 'causeth sleep, troubleth the mind, bringeth madnesse if a few of the berries be inwardly taken, but if more be taken they also kill...'. He was also aware that the alkaloids could be absorbed through the skin for he notes that a poultice of the leaves applied to the forehead, induces sleep, and relieves headache. The whole plant contains the anticholinergic alkaloid atropine, which blocks the peripheral actions of acetylcholine in the parasympathetic nervous system. Atropine is a racemic mixture of d- and l- hyoscyamine. Atropine, dropped into the eyes, blocks the acetylcholine receptors of the pupil so it no longer constricts on exposure to bright light - so enabling an ophthalmologist to examine the retina with an ophthalmoscope. Atropine speeds up the heart rate, reduces salivation and sweating, reduces gut motility, inhibits the vertigo of sea sickness, and is used to block the acetylcholine receptors to prevent the effects of organophosphorous and other nerve gas poisons. It is still has important uses in medicine. Atropine poisoning takes three or for days to wear off, and the hallucinations experienced by its use are described as unpleasant. We have to be content with 'madness', 'frenzie' and 'idle and vain imaginations' in the early herbals to describe the hallucinations of atropine and related alkaloids as the word 'hallucination' in the sense of a perception for which there is no external stimulus, was not used in English until 1646 (Sir T. Browne, 1646). It is a restricted herbal medicine which can only be sold in premises which are registered pharmacies and by or under the supervision of a pharmacist (UK Medicines and Healthcare Products Regulatory Agency (MHRA)). Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • Tyrosine phosphatase catalytic domain
  • Tyrosine phosphatase catalytic domain
  • Tyrosine protein-kinase Src,a proto-oncogene
  • Tyrosine protein-kinase Src,a proto-oncogene
  • Tyrosine protein-kinase Src,a proto-oncogene
  • Antidepressant drug blocking dopamine transporter protein
  • Action of SSRIs and NRIs
  • Action of SSRIs and NRIs
  • Action of SSRIs and NRIs
  • Sangtec Medical : postal address: AB Sangtec Medical, Box 20045, S-161 02 Bromma, Sweden ...
  • Injected fibroblast cells in culture
  • 12th self-portrait.
  • 12th self-portrait.
  • Do not be deceived! : AIDS and cancer are curable! / A.S.M.M.