Contributions to the study of the connection between chemical constitution and physiological action / by T. Lauder Brunton and J. Theodore Cash.

  • Brunton, T. Lauder (Thomas Lauder), 1844-1916.
Date:
[1891?]
Catalogue details

Licence: Public Domain Mark

Credit: Contributions to the study of the connection between chemical constitution and physiological action / by T. Lauder Brunton and J. Theodore Cash. Source: Wellcome Collection.

Provider: This material has been provided by the Augustus C. Long Health Sciences Library at Columbia University and Columbia University Libraries/Information Services, through the Medical Heritage Library. The original may be consulted at the the Augustus C. Long Health Sciences Library at Columbia University and Columbia University.

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    V VII [. Contributions to the Study of the Connection between Chemical Constitution and Physiological Action.—Part II. By T. Lauder Brunton, M.D., F.R.S., and J. Theodore Cash, M.D., F.R.S. Received March 2,—Read March 5, 1891. It is now more than four years since this research was begun, and it has necessitated such a large number of experiments that, if given in detail, they would till several hundred pages, and, therefore, only a brief account of the results, with details of a few typical experiments, can be given here. During the time we have been engaged in this research a great deal of work upon the physiological action of aromatic compounds has been done by other observers ; but upon trying to collate their results, with a view to arriving at some general conclusions, it appeared that the conditions under which the various experiments have been carried out have differed to such an extent as to render comparison very difficult. In this research we have endeavoured to perlorm our experiments as nearly as possible under the same conditions, so that the results should be comparable. We have employed bodies of comparatively simple constitution, so that differences in their physiological action might be readily connected with differences in their chemical structure. Plan of the Research. The plan of the present research to a certain extent resembles that of our former investigations into the action of the compound ammonias. We have studied: 1st. The alterations in action which occur when an atom of hydrogen in benzene is replaced by haloid radicles. 2nd. The action of the compounds formed when one, two, or mure atoms of hydrogen are replaced by alcohol radicles. 3rd. The alterations produced by the introduction of one, two, or three atoms of hydroxyl. 4th. The alterations produced by the replacement of one hydrogen atom by the radicle NO,. 5th. By the replacement of one hydrogen atom by the amidogan radicle (NBUJ. MDCCUXCI.—B. 4 A 2 oU. 12.91