Contributions to the study of the connection between chemical constitution and physiological action / by T. Lauder Brunton and J. Theodore Cash.

  • Brunton, T. Lauder (Thomas Lauder), 1844-1916.
Date:
[1891?]
Catalogue details

Licence: Public Domain Mark

Credit: Contributions to the study of the connection between chemical constitution and physiological action / by T. Lauder Brunton and J. Theodore Cash. Source: Wellcome Collection.

Provider: This material has been provided by the Augustus C. Long Health Sciences Library at Columbia University and Columbia University Libraries/Information Services, through the Medical Heritage Library. The original may be consulted at the the Augustus C. Long Health Sciences Library at Columbia University and Columbia University.

    13/94 (page 555)
    146m. As before. General lurching of the body is frequent. 241'. All reflexes are present, but slow and tremulous. Jerkings of limbs and lurchings of body whilst sitting still. On stimulating the foot the leg is withdrawn slowly and with a jerking movement. Circulation in the web is slow and unsteady. Vessels are dilated. Pigment cells contracted. Action of Heat. Heat increases the action of the substance, rendering the jerking greater at first, and then rapidly lessening the reflexes, which are restored again by cold. Experiment. Froc4 of 27 grms. 0h 0m. One minim of monochlorobenzene was injected into the dorsal lymph sac. 65m. Tremor on movement is now well marked. Frog was put into a hot bath at 29° C. Jerking at first was much increased, but soon became reduced. 10m after immersion reflex is almost entirely gone, but there is still twitching on stimulation of foot. (Control animal remains active.) Seems to recover somewhat when taken out of the bath. It was again placed in hot water at 29° C. 20™. A slight tremor of the adductors was the only sign of reflex left. It was now placed in an ice chamber. Temperature, 7° C. In 5m the reflex was much increased; some active spontaneous movements likewise occurred. 30m after being placed in the ice chamber, reflex, though slow from cold, was active in all paits. Again placed in warm bath. In 15m all reflex was completely gone. It was now taken out and covered with ice. In 5m it was endeavouring to shake ice off. In 20' all reflexes were present; it drew its legs up strongly. Sits up well. All reflexes active and without tremor. Crawls well; does not attempt to hop. Next morning. After being 15m in bath at 29° C. hops and springs well, and has, to a large extent, regained power of movement. Monobromobenzcne. (C,;H5Br.) This compound appears to cause more lethargy and less tremor than chlorobenzene. Experiment. Frog of 32 grms. 0'' 0m. Injected I minim of monobromobenzene into the dorsal lymph sac. 40m. The springs are only a few inches in extent. It hops along the bench if left to itself, but is somewhat lethargic. 55m. On touching the eye there is a start of the whole body. 85,n. It crawls. It can only spring from 2 to 3 inches at a time unless much roused. There is tremor in the limbs and trunk after a spring. Tremor is also provoked by tapping over the 4 B 2