Contributions to the study of the connection between chemical constitution and physiological action / by T. Lauder Brunton and J. Theodore Cash.

  • Brunton, T. Lauder (Thomas Lauder), 1844-1916.
Date:
[1891?]
Catalogue details

Licence: Public Domain Mark

Credit: Contributions to the study of the connection between chemical constitution and physiological action / by T. Lauder Brunton and J. Theodore Cash. Source: Wellcome Collection.

Provider: This material has been provided by the Augustus C. Long Health Sciences Library at Columbia University and Columbia University Libraries/Information Services, through the Medical Heritage Library. The original may be consulted at the the Augustus C. Long Health Sciences Library at Columbia University and Columbia University.

    12/94 (page 554)
    We shall now record three experiments selected as typical from others made with monochlorobenzene—the first at room temperature, the second under- the action ot cold, the third with heat. Monochlorobenzene. (CGH5C1.) This substance causes in Frogs weakness, tremor, especially on movement, and inco- ordination of a character which reminds one of locomotor ataxy in Man. The circu- lation is little affected. The pigment cells are contracted. Experiment. Rana Temporaria of 24 grms. weight. Nov. 3rd. One minim of monochlorobenzene was injected into the dorsal lymph sac. Laboratory tempera- ture 60° F. 45m. After injection. Slight tremulonsness, both when attempting movement and when taken np. 87m. On stimulation of foot both legs thrown out in a slapping fashion, and there is much tremor and twitching of the head, limbs, and trunk. Frog ci'awls slowly and tremulously. Cannot hop. Kicking with legs is kept up for a long time (once for 20s) after stimulation of foot. 100m. It cannot crawl; can only draw the legs up with great labour and jerking. Circulation active. Pigment cells contracted to balls. 130m. The brain was now destroyed by pegging. 135m. Reflex is recovering, and there is slow withdrawal of the foot with great tremor. Tremor and some jerking still occur when no stimulation is applied. 241'. Next day it lies with its legs out. Any toiich of the foot is followed by tremulous movements of the feet and hands, but no withdrawal of the leg. On decapitating the animal and opening the lymph sac, it was found to contain some unabsorbed monoch lorobenzene. The spinal cord was now destroyed from above downwards till reflex was almost gone. Much of spontaneous tremor now lost, but on pinching toe there was jerking of both legs. Action of Cold. Cold lessens the action of the substance, reducing the tremor and making the movement slower. Experiment. Frog of 25 grms. 0'1 0m. One minim of monochloi-obenzene was injected into the dorsal lymph sac after exposure to cold (7° C.) for 25 minutes. 21™. No tremor, but great lethargy. If taken out, it crawls forward very slowly, drawing the legs up with remarkable slowness. 56m. Tremor is now distinct, though modified by the torpor of cold. 96m. Distinct tremor to some extent; the frog feels markedly cold. 130'. It makes springing movements, but does not change its position. Is much more normal than the Frog (similarly poisoned) at the room temperature, 60° F.