Aging at the molecular level / edited by Thomas von Zglinicki.

Dordrecht ; Boston : Kluwer Academic, [2003], ©2003.

x, 248 pages : illustrations ; 25 cm.

Copy 1 Donor: Wellcome Trust Sanger Institute.

Editorial: About the series "Biology of aging and its modulation" / S. Rattan -- Free radical production and antioxidant defense: a primer / Nicolle Sitte, Thomas von Zglinicki -- Oxidative DNA damage and repair--implications for aging / Erling Seeberg -- Oxidative damage to proteins / Nicolle Sitte -- Ageing rate, mitochondrial free radical production and constitutive sensitivity to lipid peroxidation: insights from comparative studies / Reinald Pamplona, Gustavo Barja -- Genomic instability in human premature aging / Vilhelm A. Bohr, Patricia L. Opresko -- Oxidative damage, somatic mutations and cellular aging / Rita A. Busuttil, Miguel Rubio, Martijn E.T. Dolle, Judith Campisi, Jan Vijg -- Mitochondria and aging / Martin Barron, Doug Turnbull -- Biological clocks in the aging cell / Petra Boukamp -- Telomeric damage in aging / Thomas von Zglinicki -- Probing the in vivo relevance of oxidative stress in aging using knockout and transgenic mice / Florian L. Muller, James Mele, Holly Van Remmen, Arlan Richardson -- Non-oxidative modification of DNA and proteins / Alan R. Hipkiss -- Transcriptional and translational dysregulation during aging / Suresh I.S. Rattan -- Metabolic regulation of gene silencing and life span / Haim Y. Cohen, Kevin J. Bitterman, David A. Sinclair -- The proteasome in aging / Geraldine Carrard, Bertrand Friguet -- Aging and lysosomal degradation of cellular constituents / Alexei Terman, Ulf T. Brunk.

Includes bibliographical references and index.