Genetic studies in mental subnormality.

Date:
1973
Catalogue details

Licence: Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)

Credit: Genetic studies in mental subnormality. Source: Wellcome Collection.

    9/100 (page V)
    TABLE OF CONTENTS page Foreword by J. A. Fraser Roberts .......... ix PART I FAMILIAL IDIOPATHIC SEVERE SUBNORMALITY : THE QUESTION OF A CONTRIBUTION BY X-LINKED GENES By B. C. CLARE DAVISON Chapter I Chapter II Chapter III Chapter IV Chapter V Chapter VI Introduction ........... I The Literature .......... 2 Findings in studies of hospital and other populations of mental defectives . 2 Reports of individual families where severe mental deficiency was thought to be inherited as an X-linked recessive trait .... 2 Findings in surveys of various populations of mental defectives where authors considered the possibility of an X-linked contribution . . 3 Studies where families were ascertained and then classified according to whether only males, only females or both sexes were affected . . 3 The Study of Families in the Oxford Area Where Two or More Members were Severely Defective ...... 4 Reasons for methodology adopted ....... 4 Ascertainment of families ......... 4 Elimination of further families after more complete investigation . . 5 Separation of the remaining 171 families into groups where the cause was known and those which could be regarded as idiopathic . . 5 Patterns of Distribution of Gases of Idiopathic Severe Mental Defect in 141 Families ........ 7 Pedigree evidence for X-linked recessive or sex-limited autosomal inheritance in those families with only males affected ..... 8 Pedigrees of families where both males and females or only females were severely subnormal ......... 9 Consanguinity in families where members were severely subnormal . . 11 Clinical similarities in sibs who were severely subnormal . . . 13 Numerical Approaches to Testing the Hypothesis that there is a Contribution to Idiopathic Severe Subnormality by X-Linked Gene Mutations ......... 14 Analyses designed to test the hypothesis that the male excess of affected cases is predominantly determined by X-linked recessive or sex-limited autosomal dominant genes . . . . . . . . 14 Analyses designed to test the hypothesis that genetical predisposition to severe subnormality is polygenic and that the excess of males results from a lower threshold in that sex . . . . . . 17 Dermatoglyphic Findings in Patients with Idiopathic Severe Subnormality . . . . . . .21 Findings in the study . . . . . . . . .21 Recapitulation and Discussion . . . . . . 25 Summary of the evidence of a contribution by X-linked genes to idiopathic severe subnormality ......... 27