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Growth hormone receptor, molecular model

T.Blundell & N Campillo

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Credit: Growth hormone receptor, molecular model. Credit: T.Blundell & N Campillo. CC0 1.0 Universal

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Molecular model of growth hormone (GH) and its receptor GHR), ribbon diagram. Representation of the general architecture of the 1:2 complex (PDB code:3hhr). 2 receptor molecules in cyan and blue, GH represented as cylinders. GH elicitis a variety of biological activities mainly mediated by the GHR. GH binds to two receptors mols., thereby inducing signal transduction through receptor dimerization. GH, secreted from the anterior pituitary lobe, has multiple effects on growth, metabolism and the immune system.


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