On the alterations in the red globules in malaria infection, and on the origin of melanæmia : memoir / by Ettore Marchiafava and A. Celli ; translated and edited by Edward Drummond.

  • Marchiafava, Ettore, 1847-1935.
Date:
1888
Catalogue details

Licence: Public Domain Mark

Credit: On the alterations in the red globules in malaria infection, and on the origin of melanæmia : memoir / by Ettore Marchiafava and A. Celli ; translated and edited by Edward Drummond. Source: Wellcome Collection.

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    0’003 ; their contour rnarked by a very fine line ; thè body transparent except in thè centre, where there exists a spot formed of blackish granules ; often on thè concave side is seen a fine line uniting thè two extremities of thè half moon. 2nd. Spherical transparent bodies, of thè mean diameter of a red globule containing pigment granules, which in repose often describe a very regular circle, and when in movement are actively •agitated. Sometimes at thè periphery of these elements are observed very fine filaments, which are apparently inserted into them, are animateci by very rapid movements, and bave thè free extremity slightly swollen. Such filaments may ho detached, and move freely in thè midst of thè red globules. 3rdly. Spherical elements, of irregular form, transparent and finely granular, diameter 0'008—O'OIO mm., containing pig- ment granules disposed very irregularly at thè periphery, some- times collected in thè centre, sometimes at a point of thè periphery itself. There are also found in thè blood, according to Laveran, spherical transparent elements, containing movable and im- movable pigment granules, elements of smaller diameter than thè preceding, isolated or united, and adhering to thè red discs and thè leucocytes. Laveran believes that these pigmented bodies represent different stages of an elementary parasite, which he is unable to pronounce to be animai or vegetable, which exists in an encysted condition, and in its perfect form becomes free as a movable Jilament. Besides these, Laveran lias observed in thè blood stimine-, round, movable bodies, without specific character ; melaniferous leucocytes, red globules which appear perforated in ono or more points, inclosing pigmentary granulations, free pigment granules resulting from thè destruction of thè parasitic elements. Richard * confirms fully thè observations of Laveran, but instead of holding, like this observer, that thè small pigmented forms are found adhering to thè red corpuscles, he maintains that they, existing within thè latter, where they are developed, grow and issue from them in a perfect state. He describes these pigmented parasites in various stages of development in thè red globules, when arrived at a state of maturity perforating * Sur le parasite de la Malaria. Comptes rendus (1882). 5