Conversations in genetics. Vol. 2, No. 5: Talking with Janet Rowley.

Recorded on May 6, 2004, at the Cummings Life Sciences Center at The University of Chacago, Chicago, IL., Alfred Knudson, Senior Member, Division of Population Science, Fox Chase Cancer Center, Philadelphia, PA., talks to Janet D. Rowley, Blum-Riese Professor of Medicine and Human Genetics, The university of Chicago. Rowley has been an international leader in cancer research for more than thirty years, beginning with her critical discovery that cancer can be caused by a specific reciprocal translocation chromosomal rearrangement. She and others subsequently found a multitude of other specific translocations that underlie many sarcomas, leukemias and lymphomas, and showed that their common mechanism is activation or creation of an oncogene that stimulates cell proliferation or interferes with programmed cell death. Her work continues to illuminate cancer research and to bring her many honours, including the National Medal of Science, the Lasker Award, the Gairdner Foundation Award, and the Benjamin Franklin Medal.