Report on some of the changes produced on liver cells by the action of some organic and inorganic compounds / by T. Lauder Brunton and S. Delépine.

  • Brunton, T. Lauder (Thomas Lauder), 1844-1916.
Date:
[1894]
Catalogue details

Licence: Public Domain Mark

Credit: Report on some of the changes produced on liver cells by the action of some organic and inorganic compounds / by T. Lauder Brunton and S. Delépine. Source: Wellcome Collection.

Provider: This material has been provided by The University of Glasgow Library. The original may be consulted at The University of Glasgow Library.

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    Provisional Conclusions. The effect which the administration of various drugs has on the distinctness of the cellular mitoma and on the distribution or arrange- ment of that mitoma and of the paramitoma, resembles, in the case of a certain number of drugs, that of pilocarpine, and in others that of atropine. The first drugs may be said to stimulate glandular activity, the latter to restrain it; only a few of those experimented with seemed to have neither a stimulating nor a depressing action. On this basis we may subdivide the compounds studied into three groups. 1. Stimulating or excito-secretory group, with pilocarpine for a type. 2. Neutral group. 3. Depressing or depresso-secretory group, with atropine for type. 1. JSxcito-secretory group. Of the following compounds, those heading the following list pro- duced the most marked changes in the mitoma of the cells:— Toluene, benzol, sodium iodide, pilocarpine, chrysophanic acid, ammonium chloride, toluylene diamine, nitric acid. (Aniline seemed in one case to have a stimulating effect, but this was doubtful.) 2. Neutral group. ~No drug was altogether neutral, but two drugs seemed to have little depressing, and still less exciting, action, though they evidently produced degenerative changes in the cells; in the doses used, they acted probably too powerfully as poisons. These compounds were aniline and phenol. 3. Depresso-secretory group. The following compounds belong to this group :— Phenol, atropine, ammonia. In each of the two great groups it is possible to recognise marked differences based on the influence which the drugs had (1) on the storage of glycogen; (2) on the accumulation of compounds giving the reaction of inorganic ferric salts in the liver. 1. In the excito-secretory group. * Glycogenic Function. A. —The following drugs caused marked increase of glycogen in the liver:— Sodium iodide, toluylene, diamine, chrysophanic acid (toluene?) (ammonium chloride ?) B. —The following gave rise to no marked increase of glycogen, and sometimes even to a diminution :— (Ammonium chloride P), nitric acid, pilocarpine, benzol.