Report on some of the changes produced on liver cells by the action of some organic and inorganic compounds / by T. Lauder Brunton and S. Delépine.

  • Brunton, T. Lauder (Thomas Lauder), 1844-1916.
Date:
[1894]
Catalogue details

Licence: Public Domain Mark

Credit: Report on some of the changes produced on liver cells by the action of some organic and inorganic compounds / by T. Lauder Brunton and S. Delépine. Source: Wellcome Collection.

Provider: This material has been provided by The University of Glasgow Library. The original may be consulted at The University of Glasgow Library.

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    [From the Proceedings of the Royal Society, Vol. 55 J Report on some of the Changes produced on Liver Cells by the Action of some Organic and Inorganic Compounds. By T. Lauder Brunton, M.D., F.R.S., and S. Delepine, M.B. Received March 14, 1894. We have, on a former occasion, given an account of the scope of the investigation, and of the methods used, of some preliminary observations* which we have found it necessary to make. Briefly speaking, our ohject was to ascertain the action of drugs on the cells of the liver and to connect, if possible, the changes in the cells with the physiological action of the drugs and their chemical structure. Certain drugs were selected hy one of us (Brunton) as being most suitable for this investigation. These drugs were the follow- ing :— Benzene C6H6-H Phenol C6H5-OH Toluene C6H6-CH3 Aniline C6H5-NH2 fCH3 (1) Toluylene diamine (meta) C6H3<J NH2 (3) InH2 (4) Chrysophanic acid C10H4O4 Pilocarpine nitrate CuH16N2CyHN03 f tr°Pine (0„HaN08)8HaSO« Ammonia NB:3 Ammonium chloride NH^Cl Nitric acid HN03 Sodium iodide Nal We have recorded the various appearances which we have observed as the result of the purely physiological stimulation of the liver produced by the ingestion and digestion of a meal, and have noticed that the most important changes indicating various states of activity were :— 1. The size of the cells. 2. The distinctness of the mitoma and of the cellular cleavage. Aro^T S°C- Pr0C•'' 0Cfc 22' 1891' V0L 5°' P- 209> Pl-d in the 6