The influence of kairin, thallin, hydrochinon, resorcin, and antipyrin, on the heart and bloodvessels / by H.G. Beyer.

  • Beyer, Henry Gustav, 1850-1918.
Date:
[1886]
Catalogue details

Licence: Public Domain Mark

Credit: The influence of kairin, thallin, hydrochinon, resorcin, and antipyrin, on the heart and bloodvessels / by H.G. Beyer. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

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    sisted in cutting out the heart and inserting canulas into the aortic trunks and one canula into the sinus. The aortic canulas were connected with Mariotte's flasks, placed at a certain height above the body of the animal, from which flasks liquid was made to flow into the arteries. This liquid, after circulating through the capillaries and veins, was drained off from the sinus into a beaker and measured at definite intervals. After this outflow had become constant, circulating fluid plus the drug was substi- tuted for the normal circulating fluid, and the action of the drug on the vessels determined from the change which took place in the amount of the outflow in a unit of time. A decreased outflow indicated increased resistance to the flow of the fluid through the vessels, or, in other words, a constriction of them, and an increased outflow, a dilatation of them. Parallel observations were made on both frogs and terrapins according to the methods thus briefly outlined. Observations on bloodvessels were also made according to a method recently employed by Kriiger, of Berlin, and of which a short account was found in the December number of the Therapeutic Gazette for 1885. In these observations, the frogs were curarized just sufficiently to abolish all voluntary and reflex movements; the animal was then placed on a glass plate armed with a cork ring, on which the tongue was fast- ened with needles in the usual manner, so as to expose its under surface ; being ke2)t moist with normal salt solution, it was examined under the microscope with a magnifying jDower of sixty diameters. After selecting from the mass of bloodvessels a certain small vein, a capillary and an arteriole, the outlines of which were the most clearly defined, outline drawings of them were made through a camera (Oberhauser's), and careful measurements of them taken in millimetres. All observations were confined to certain short sections of the vessels thus selected. During the first ten minutes several measurements Avere made and carefully compared, and when it was found that they became uniform, the drug was either injected into one of the lymph-sacs, or applied in solution or in substance to the surface of the tongue, a short distance away from the point which was directly under the objective, so as not to interfere with the clearness of the field. It was found best to select small sections of clear and well-defined vessels, and confine all subse- quent observations and measurements to them, in order to insure uni- formity. The drug once administered, drawings of the vessels were made every five minutes, carefully measured and recorded. As a rule, these observations were not continued much over an hour, and some of i them had to be discontinued even before the end of that time for reasons hereafter to be stated. Before, however, taking up the experiments on the heart and blood- vessels, it is perhaps best to consider here the few points ascertained with regard to the action of these drugs upon the blood itself.