T.N.T. poisoning and the fate of T.N.T. in the animal body.

Date:
1921
Catalogue details

Licence: Public Domain Mark

Credit: T.N.T. poisoning and the fate of T.N.T. in the animal body. Source: Wellcome Collection.

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    T.N.T. is scarcely complete without some mention of the similar action of other toxic substance. The blood changes and liver necroses had been previously found to occur in benzol poisoning by Selling (18), Klemperer and Hirsch- feld (14), and Heffter (15). The production of jaundice in animals by toluylenediamine was described by Stadelmann (16). Blood changes, but of a different nature are commonly present among dinitrobenzene workers and were described by Malden (17). Fatal cases of toxic jaundice due to this drug are rare, but a case is described by Spilsbury (10), together with five fatal cases of ‘ aero¬ plane dope ’ poisoning with very similar liver changes. The poisonous substance in aeroplane dope was first shown by Heffter and Joachi- inoglu (18) to be tetrachlorethane. Marked destruction of the liver parenchyma has occurred, but to a very variable extent, in spiro- chaetosis ictero-haemorrhagica (19). Very similar lesions have been found in the liver in sporadic cases of acute yellow atrophy of un¬ known cause, and more recently in salvarsan poisoning. The lesions in the salvarsan cases are described by Dr. Turnbull (20) as almost identical with those set up by T.N.T. In phosphorus poisoning fatty degeneration is a more conspicuous feature. References. (1) White and Hay Lancet, August 31, 1901, p. 582. (2) Moore, B., Medical Research Committee Special Report Series, No. 11, 1917. (3) Koelsch, F., Centralbl. f. Gewerbehygiene, March-July 1917. (4) Koelsch, F., Centralbl. f. Gewerbehygiene, October 1917. (5) Webster, T. A., Lancet, 1916, ii, 1029. (6) Tutin, F., Lancet, 1918, ii, 554. (7) Stewart, M. J., Lancet, 1917, i, 153. (8) Panton, P. N., Lancet, 1917, ii, 77. (9) Payton, P N., Report to T.N.T. Advisory Committee, April 1917. (10) Proc. Roy. Soc. Med., Toxic Jaundice, 1917. 10, No. 5, p. 1. (11) Martland, Proc. N. York Path. Soc., October 1916, p. 129. (12) Oertel, H., Canada M. Ass. J., 1917, 7, 281. (13) Selling, L., Bcitr. z. path. Anat., 1911, 20, 577. (14) Klemperer u. Hirschfeld, Therap. d. Gegenw., 1913, 54, 57. (15) Heffter, A., Deutsche Med. Wchnschr., 1915, 62, 182. (16) Stadelmann, E., Der Icterus und seine verschiedenen Formen, Stuttgart, 1891. (17) Malden, W., J. Hyg., 1907, 7, 672 and Minutes of Evidence, Committee on Compensation for Industrial Diseases, Cd. 3496, p. 384. (18) Grim, Heffter, u. Joachimoglu, Vrtljschr.f. gcrichtl. Med., 1914, 48, supp. p. 32. (19) Dawson, B., Lancet, 1913, ii, 575. (20) Turnbull, Reports to Salvarsan Committee, McdAcal Research Council, Special Report Series, No. 55, 1920. (21) Haldane, Makgill and Mavrogordato, J. Physiol., 1897, 21, 160. i l \