Leprosy: skin

  • SB Lucas
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Leprosy: skin. SB Lucas. CC0 1.0 Universal. Source: Wellcome Collection.

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Description

Borderline tuberculoid (BT) leprosy: skin This is a medium power view of a skin section from a patient with BT. It shows brown HLA-DR staining in macrophages and in the epidermis. Immunostain with monoclonal antibody 1B5. This epidermal staining is not normal. HLA-DR expression by the epidermal cells has been switched on by secretion of cytokines from the underlying granulomatous inflammation. Lymphocytes react to the presence of Mycobacterium leprae antigen by secreting interferon-gamma, which up-regulates HLA-DR expression. A similar mechanism may underlie type 1 reaction. See images W003367 and W003367 for H&E stained sections from this patient.

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