The subcutaneous injection of quinine in malarious fevers : a paper read before the International Medical Congress at Amsterdam, in September, 1883 / by J.B. Scriven.

  • Scriven, J.B.
Date:
[1883]
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Licence: Public Domain Mark

Credit: The subcutaneous injection of quinine in malarious fevers : a paper read before the International Medical Congress at Amsterdam, in September, 1883 / by J.B. Scriven. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

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    THE SUBCUTANEOUS INJECTION OF QUININE IN MALARIOUS FEVERS. ^^MONGST the vast number of cases of intermittent and re- mittent fever, that present themselves to a practitioner of medicine in a malarious country, a certain number will be found not amenable to quinine taken by mouth or rectum. In such cases he naturally looks for some other mode of administration ; and in such only is the subcutaneous method recommended in this paper. As long ago as 1862 quinine was thus given by Dr. Chas- seaud, physician to the hospital of St. Antonio, at Smyrna. (See the Medical Times and Gazette of Aug. 2, 1862, p. 20). This is the first record I have been able to find, though Dr. Charles of Calcutta, and Dr. Moore of Bombay, appear to have adopted the practice earlier. Dr. Charles had 100 cases, in which he employed with good results and without untoward consequences, a saturated solution of quinine in dilute sulphuric acid ; this injection, however, produced intense though transient pain at the moment of the operation. He afterwards used the liquid known as amor- phous quinine. Dr. Moore wrote in the Lancet of August i, 1863, p. 126, that he had treated upwards of 30 cases by subcutaneous injec- tion, with almost invariable success, using a solution of thirty grains of-quinine in half an ounce of water, with eight or ten drops of dilute sulphuric acid. Others, myself among the number, adopted a similar prac- tice. Most of those, who have recorded their observations, have agreed in the potency of the hypodermic treatment for checking the fever, though many have relinquished the practice on account