Whole arm translocation, centromere probes

Human chromosomes highlighted by fluoresent probes that bind to specific sequences of DNA. Centromere specific probes have been used to determine the break-points in a whole arm translocation between chromosomes 11 (green cnetromeres) and 14 and 22 (red centromeres). This patient has inherited the der(11), and is therefore trisomic for the whole of 11p. Image by Dr John Crolla.