A third active principle in ergot extracts : (preliminary note) / by George Barger and Henry Hallett Dale.

  • Barger, George, 1878-1939.
Date:
[between 1910 and 1919?]
Catalogue details

Licence: In copyright

Credit: A third active principle in ergot extracts : (preliminary note) / by George Barger and Henry Hallett Dale. Source: Wellcome Collection.

    1/2
    16 *133. “A third active principle in ergot extracts.” (Preliminary note.) By George Barger and Henry Hallett Bale. In addition to the active principles previously described by the authors as present in ergot and its extracts, namely, ergotoxine (Trans., 1907, 91, 337 ; Biochem. J., 1907, 2, 286) and ^-hydroxy- phenylethylamine (J. Physiol., 1909, 38, lxxvii; Trans., 1909, 95, 1123), there remained for identification the substance responsible for the intense activity exhibited by some ergot extracts in producing contraction of the isolated, non-pregnant uterus of the cat (compare .Kehrer, Arch. exp. Path. Pharm., 1908, 58, 366). As Kehrer found, this action is specially characteristic of Wernich’s Ergotinum dialysatum. The relative abundance of this principle in dialysed extracts suggested that it was wholly or partly produced by micro-organisms, and this supposition was confirmed by physio-