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Angiotensin and hypertension in pregnancy.

Date
1979
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Licence

Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
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Credit: Angiotensin and hypertension in pregnancy. Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)

About this work

Description

A discussion between Dr. Fiona Broughton Pipkin, University of Nottingham, and Mr. Geoffrey Chamberlain. The following summary accompanies the cassette: "Angiotensin II (AII) is an extremely powerful vascoconstrictor hormone, formed by the action of the enzyme renin on an -d-globulin substrate. Levels of renin and AII are high inn normal pregnancy but a specific compensatory diminution in vascular reactivity probably via PGEs, protects against hypertension. In hypertensive pregnancy (PIH), this protection is lost, and levels of AII are usually still further increased. There is a positive statistical relationship between diastolic BP and AII levels in pregnancy in humans and sheep. The administration of an AII receptor blocker to conscious pregnant sheep evokes a dose-dependent fall in blood pressure, the size of which is proportional to initial AII levels. There is also increasing indirect evidence that the feto-placental unit may contribute to circulating ALL levels. It is suggested that the relative ischaemia of the feto-placental unit in PIH results in increased AII production, as in the ischaemic kidney. This then results in increased PGE production in the uterus, which, together with the increased systemic BP improves feto-placental perfusion. This PIH may initially be a physiological response on the part of the feto-placental unit."

Publication/Creation

London : University of London Audio-Visual Centre, 1979.

Physical description

1 encoded moving image (30.28 min.) : sound, black and white.

Duration

00:30:28

Copyright note

University of London

Terms of use

Unrestricted
CC-BY-NC
Creative Commons Attribution-Non-Commercial 2.0 UK: England & Wales

Language note

In English

Creator/production credits

Discussed by Mr Geoffrey Chamberlain and Dr Fiona Broughton-Pipkin, University of Nottingham. Medical editor: Mr Geoffrey Chamberlain. Produced by Jennie Smith. Lithograph courtesy of Henry Moore OM. Made by University of London Audio-Visual Centre. Made for Postgraduate Medical Federation in association with The Blair Bell Research Society.

Notes

This video is one of around 310 titles, originally broadcast on Channel 7 of the ILEA closed-circuit television network, given to Wellcome Trust from the University of London Audio-Visual Centre shortly after it closed in the late 1980s. Although some of these programmes might now seem rather out-dated, they probably represent the largest and most diversified body of medical video produced in any British university at this time, and give a comprehensive and fascinating view of the state of medical and surgical research and practice in the 1970s and 1980s, thus constituting a contemporary medical-historical archive of great interest.

Contents

Segment 1 Chamberlain introduces the discussion. Broughton-Pipkin explains what angiotensin is and what functions it has in the body. Time start: 00:00:00:00 Time end: 00:04:30:00 Length: 00:04:30:00
Segment 2 Broughton-Pipkin explains what happens to hormones during a normal pregnancy compared to changes which occur in a hypertensive pregnancy. She shows a graph detailing angiotensin II levels in pregnant women. Time start: 00:04:30:00 Time end: 00:09:45:00 Length: 00:05:15:00
Segment 3 Broughton-Pipkin shows a table listing angiotensin II levels in pregnant women and their babies - both are raised and she explains why this is so. Time start: 00:09:45:00 Time end: 00:14:20:13 Length: 00:04:35:13
Segment 4 We are shown a graph which plots the effectiveness of the angiotensin receptor blocker medication, saralasin. A further table shows how maternal angiotensin II levels fall after delivery of the baby. Time start: 00:14:20:13 Time end: 00:19:46:19 Length: 00:05:26:06
Segment 5 Broughton-Pipkin talks about renin which increases angiotensin II production. A further diagram shows stages of foetoplacental blood flow. Then she and Chamberlain are shown seated in discussion. Time start: 00:19:46:19 Time end: 00:24:57:11 Length: 00:05:10:17
Segment 6 Chamberlain and Broughton-Pipkin discuss the problems of giving medicines to treat hypertension to pregnant women. They are both of the mind that the hypertension is there for a valid reason during pregnancy and that it should only be aggressively treated if it is leading to complications. Time start: 00:24:57:11 Time end: 00:30:28:19 Length: 00:05:31:08

Languages

  • English


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