Volume 7

Treasury of human inheritance / edited by Karl Pearson, R.A. Fisher, L.S. Penrose.

Date:
1909-
Catalogue details

Licence: Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)

Credit: Treasury of human inheritance / edited by Karl Pearson, R.A. Fisher, L.S. Penrose. Source: Wellcome Collection.

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    saw well. III. 2, the father, aged 73, saw well. III. 3, the mother, died at 53, from a disease of the liver- Three brothers, IV. 10, died at the age of a few months; IV. 11 died aged 11, IV. 12 died aged 15 months and IV. 13 died aged 13 years. IV. 1, female, aged 53, saw well. IV. 2, J. B., born 1860, became affected 1882, when on military service; the condition progressed for five months and then became stationary; in 1911 both discs were white; arteries very narrow, veins tortuous, peripheral limits of fields normal; It. V. = L. V. = hand movements. IV. 3, A. B., born 1862, became affected 1883; in 1911, It. V. = finger counting at 50 cm., L. V. = finger counting at 1 m.; pupillary reactions sluggish; discs were white with blurred margins, arteries narrow, veins normal; peripheral limits of fields normal. IV. 4, female, aged 47, saw well. IV. 5, K. B., born 1868, became affected 1895; after four months, during which time he was treated with mercury and potassium iodide, vision was reduced to hand movements at L m.; in 1911 V.=perception of light; neuritic atrophy was noted. IV. 6, aged 44, had always seen well until five months ago when she had a sudden diminution of vision; she had rachitis as a child and rheumatism since but was otherwise healthy; her five children were healthy and saw well; R. V. = finger counting at 30 cm., L. V. = finger counting at 20 cm.; temporal halves of discs were white, margins blurred, arteries narrowed; central scotomata were demonstrated for all colours with normal outer limits of fields. IV. 8, female, born 1872, became affected in 1902 in the left eye only, on Oct. 2, R. V. =^, L. V. = |-, on Oct. 18, L. V. — -¡-T,, Oct. 29, L. V. =^, Oct. 30, L. V. = ■$■$, five weeks later, L. V. = the lateral half of the disc was pale and there was marked concentric contraction of the field; right eye was normal; two years later the vision in the left eye was as good as in the right; a year later again IV. 8 had a still more marked lowering of vision in the left eye which improved as before and she was now able to see to read with her left eye. IV. 9, born 187 6, became affected in 1898; in 1896 he was examined and his vision was normal, in 1899, R. V. = J, L.V.= finger counting at 2 m.; the discs were a whitish green colour, the arteries narrower than normal; large central scotomata were present; peripheral limits of fields normal. No consanguinity recorded. Bibl. Nos. 68, 96. Fig. 836. Mathieu’s Case. Hereditary optic atrophy in five males and five females of three generations. II. 3 had excellent vision up to the age of 50 when she became amblyopic in both eyes and was unable to see to sew, but could go about alone; the condition remained stationary until her death at the age of 69; her parents saw well, but a brother of her father had bad eyes; she had five brothers and two sisters who all saw well, but one of her sisters, II. 7, had affected sons. II. 3 had six children of whom III. 2 was born several years before her mother’s marriage and nothing was known of her father; she saw well up to the age of 40 when she suddenly became amblyopic in the left eye only, the right eye became affected eight years later; she had good general health but when seen at the age of 58 it was impossible for her to sew and she could scarcely see well enough to go about alone; her pupils were dilated and neither reacted to light nor to accommodation; atrophy of the optic nerve was noted, discs uniformly discoloured, arteries narrowed; R. V. = finger counting at 50 cm., L. V. can scarcely see fingers; right eye recognised blue, red and yellow, left eye recognised no colour. III. 3 died aged 2 days; III. 4 died aged 34 when her vision was just beginning to fail. III. 5, now aged 51, reported that he had a sudden onset at 22, both eyes became affected at the same time, he saw better in a dull light; pupils, now slightly dilated, reacted very sluggishly to light, more definitely to accommodation; there was bluish grey discoloration of the discs, especially in the temporal sections; arteries were narrowed; R. V. = finger counting at 20 cm., L. V. = finger counting at 30cm.; right eye recognised blue, left eye recognised yellow and blue. III. 6, female, aged 45, began to lose her vision six years ago, the defect progressed for six months during which time she had very severe temporal headaches, later she complained of giddiness; she saw better in a dim light; pupils were normal and showed normal reactions; discs were bluish grey, especially in the temporal section; arteries were narrowed, veins normal; vision reduced to finger counting in the right at 30 cm., in the left at 20 cm.; blue was the only colour recognised. III. 9 had normal vision but one of her sons was affected. II. 7, sister to II. 3, had two illegitimate sons, III. 12 and 14, by different fathers, who were affected; she also had two normal sons, III. 11 and 13, who were soldiers, and a daughter, aged 27, who was still normal; the exact parentage of these siblings or half siblings is obscure. The mother, II. 7, had good eyes at the time of her death at the age of 64. III. 12, aged 47, became affected at the age of 32, the condition progressed for a year and had since been stationary, he now saw better in a dim light; pupils were dilated and reacted feebly to light and accommodation; atrophy of the disc was present; vessels normal; R. V. = Ar> L. V. = L; both eyes became affected simultaneously. III. 14, aged 43, became affected in the right eye only at the age of 28, the left eye became affected two or three years later; pupils slightly dilated, reaction to light scarcely perceptible, no reaction to accommodation; discs were white, especially so in the temporal section, very marked narrowing of arteries is noted; absolute colour-blindness; vision in both eyes was reduced to hand movements. All the affected members of this generation had pterygium. III. 2 had fourteen children of whom three boys died young, four girls were dead at the time of the record, three sons and two daughters saw well, and one son, IV. 2, and one daughter, IV. 8, were affected. IV. 2, aged 32, had a sudden onset in both eyes at the age of 18; no history of headaches; pupils dilated, reacting feebly to light, not at all to accommodation; discs were pale, arteries slightly narrowed; R. V. = finger counting at 15 cm., L. V. = finger counting at 10 cm.; right eye recognised blue and red, left eye