Fibroblast responses to acetylcholine, Cd++

Quail fibroblast responses to suberyldicholine (SDC), shown by Ca++i signal, shown by fluorescence. A cells at rest. B peak response to dose of 10 microM SDC. C incubation in 100 microM Cd++ no effect on resting Ca level, D but blocked SDC response. E Ca++ same after washout of SDC and Cd++.Credit: Biosciences Imaging Gp,Soton Univ/WTMPL