Immunity of guinea-pigs to diphtheria toxin and its effect upon the offspring / by H.J. Südmersen and A.T. Glenny.

  • Südmersen, Henry J.
Date:
1912
Catalogue details

Licence: In copyright

Credit: Immunity of guinea-pigs to diphtheria toxin and its effect upon the offspring / by H.J. Südmersen and A.T. Glenny. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

    12/54 (page 228)
    The cases recorded in Table VIII show more or less rapid loss of immunity in the mother, but they cannot be closely analysed in con- sequence of the variation of immunity according to the age of the young which is to be dealt with next. We have demonstrated immunity to the extent of tolerating 10 fatal doses of toxin in young born 25 months after the injection of the mother. 4. The age of the young when tested for immunity. In all cases the young are tested when they have reached the weight of 250 grams, the time taken for pigs to reach this weight varies from 10 days to 120 days. Tables IX, X, XI, give the results of over 300 young whose exact ages were known. It should be noted that these tables differ from I, II, III and V, VI, VII as all the young are given irrespective of the treatment of the parents while the earlier tables recorded the mothers and not the young. TABLE IX. Age of young in days Dose tested 20 or less 21—30 31-40 41—50 51—60 Over 60 I fUnder 0*008 c. c. 2 4 2 1 7 14 Deaths < 10*008 and under 0*010 c.c. 4 21 21 12 4 1 10*010 0*020 c.c. 4 12 14 12 13 6 \ lo*020 0*030 c.c. 5 7 7 2 9 5 1 f0*008 and under 0*010 c.c. 9 10 4 1 1 0 0*010 0*020 c.c. 8 17 18 9 3 1 Survivals < 10*020 0*030 c.c. 1 7 9 4 5 0 1 [Over 0*030 c.c. 1 3 4 3 0 0 TABLE X. Doses at or above Age of young in days which young N survived and at or 20 or less 21-30 . A. 31-40 41- -50 51—60 Over 60 under which Sur- Sur- Sur- / Sur- N Sur- Sur- young died vivals Deaths vivals Deaths vivals Deaths vivals Deaths vivals Deaths vivals Deaths 0*008 C.C. 19 2 37 4 35 2 17 1 9 7 1 14 0*010 C.C. 10 6 27 25 31 23 16 13 8 11 1 15 0*020 C.C. 2 10 10 37 13 37 7 25 5 24 0 21 0*030 C.C. 1 15 3 44 4 44 3 27 0 33 0 26 Table XI shows that immunity has almost disappeared at the end of two months. But that it may occasionally be present, however, to a considerable extent after this period will be shown later when we record cases in connection with another section of the subject.