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White matter fibres of the uncinate fasciculus

Christopher Whelan, Royal College of Surgeons in Ireland

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Attribution 4.0 International (CC BY 4.0)
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Credit: White matter fibres of the uncinate fasciculus. Credit: Christopher Whelan, Royal College of Surgeons in Ireland. Attribution 4.0 International (CC BY 4.0)

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This image shows the white matter fibers of the uncinate fasciculus (connector of the temporal and frontal brain regions) in (i) a neurologically healthy individual (far left), (ii) a seizure-free temporal lobe epilepsy patient (middle) and (iii) a temporal lobe epilepsy patient suffering from secondarily-generalized tonic-clonic seizures (far right). A superior (top) view is shown in the top row and an inferior (bottom) view is shown in the lower row. The images were produced using Diffusion Tensor Imaging (DTI) as part of a study to advance the understanding of the neural connections involved in the secondarily generalisation of temporal lobe seizures. Secondarily-generalized tonic-clonic seizures (SGTCS)– frequently referred to as ‘grand mal’ attacks – are the most dangerous types of epileptic seizure. They involve a bilateral, symmetrical surge of neuronal activity which leads to both a ‘tonic’ seizure phase (principally involving rigidity, crying out, tongue biting, apnea, cyanosis and an increase in blood rate) and a ‘clonic’ phase in which the patient falls and develops intermittent clonic movements typically involving all four limbs featuring brief interludes of muscle relaxation. The precise mechanism by which these seizures spread from the site of onset to the rest of the brain is still unclear. In order to understand a potential mechanism of this seizure spread in temporal lobe epilepsy (TLE), diffusion sensor imaging was used to compare the white matter tracts in the uncinate fasciculus in healthy individuals, to those suffering from SGTCS and to patients who remained seizure-free for at least two years. The results from the study showed a significant reduction in the number and volume of white matter tracts running through the uncinate in TLE patients with SGTCS compared to seizure-free patients. Tracts were also significantly less widespread in SGTCS patients compared to seizure-free patients and controls, while the mean angle (i.e. extent of bending) of tracts was significantly increased in SGTCS patients compared to seizure-free patients.

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