Liver: penicilliosis with HIV

Penicilliosis This is a high power view of the liver in an in infection by Penicillium marneffei, a dimorphic fungus. The portal tract macrophages and Kupffer cells in the liver parenchyma contain abundant small yeasts. H&E stain. This patient presented in Hong Kong, having acquired the infection in Thailand. In Southeast Asia penicilliosis is a frequent HIV-associated disseminated infection. It parasitizes macrophages and can also produce skin lesions.