The time has come : the Harveian oration delivered before The Royal College of Physicians of London on St. Luke's Day, 1937 / by Sir Arthur Hurst.

  • Hurst, Arthur F. (Arthur Frederick), Sir, 1879-1944.
Date:
[1937?]
Catalogue details

Licence: In copyright

Credit: The time has come : the Harveian oration delivered before The Royal College of Physicians of London on St. Luke's Day, 1937 / by Sir Arthur Hurst. Source: Wellcome Collection.

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    hydrochloric acid failed to produce any striking improvement in most cases of Addison’s anaemia. It seemed clear, therefore, that although achlor¬ hydria was constantly present in Addison’s anaemia, it was not directly responsible for its development. This was the state of our knowledge on the subject when, in 1931, Castle, a young Harvard physician, who had been working with Minot on the treatment of Addison’s anaemia with liver, solved the problem in a manner which would have delighted the heart of Harvey. He first demon¬ strated that the administration of the gastric juice of a normal man had no more effect on the blood of a patient with Addison’s anaemia than an artificial gastric juice consisting of hydrochloric acid and pepsin. He then made the remarkable observa¬ tion that a mixture of meat with gastric juice was as effective as liver in the treatment of the anaemia, but that this was not a result of peptic digestion, as the gastric juice could not be replaced by hydrochloric acid and pepsin, and the mixture was most effective when the hydrochloric acid was completely neutralised so as to prevent the